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OpenTrials
Completed

NCT Number: NCT00551434

Effect of Creatine and L-Arginine on Endothelial Function

The study is a double blind 2x2 factorial study. Patients with coronary disease will be randomly be assigned to L-arginine (9 g/day), creatine 21 g/d, both, or neither dietary supplement. The function of the endothelium will be tested using ultrasound before and after each treatment. These studies will help us understand why the endothelium is abnormal in patients with coronary artery disease and how L-arginine is acting on endothelial function.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Coronary artery disease

Exclusion criteria

  • Pregnancy
  • Creatine use within one month of study
  • L-arginine use within one month of study
  • Change in dose or initiation of lipid lowering therapy, aspirin therapy, or angiotensin converting enzyme therapy within one month of study

Treatment and study plan

Creatine

Dietary Supplement

Creatine 21 g daily

L-arginine and creatine

Dietary Supplement

L-arginine

L-Arginine

Dietary Supplement

l-arginine 9 g daily

placebo, double

Dietary Supplement

placebo

Primary outcomes

  1. Brachial artery flow-mediated dilation

    Time frame: 5 days

Secondary outcomes

  1. serum arginine, creatine, creatinine, homocysteine

    Time frame: 5 days

Sponsors and collaborators

Lead sponsor

Boston University

Other

Registry information

Official study title

Effect of Creatine and L-Arginine on Endothelial Function in Patients With Coronary Artery Disease

Important dates

Study start
2002
Study completion
2005
First posted
Oct 31, 2007
Registry last updated
Oct 31, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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