Skip to main content
OpenTrials
Completed

NCT Number: NCT00553904

Effect of Cranberry Juice on Endothelial Function

A pilot study of 15 subjects will be completed to determine whether acute consumption of cranberry juice has an effect on endothelial function. We will then complete a randomized, double blind, placebo controlled crossover study designed to investigate the effects of cranberry juice consumption on endothelial function. Participants (n=40) will drink 480 ml of double strength cranberry juice or a similar appearing and tasting placebo per day for four weeks. After a two week rest period, they will cross over to the other beverage. We will examine endothelial function before and after each of the two treatment periods. The study will provide information about the chronic vascular effects of cranberry juice.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

21 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Boston Medical Center

Boston, Massachusetts, 02118, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Coronary artery disease

Exclusion criteria

  • Pregnant and lactating women
  • Clinical history of other major illness including end-stage cancer, renal failure, hepatic failure, gastrointestinal disorders that may impair absorption, or other conditions that in the opinion of the principal investigator make a clinical study inappropriate
  • Treatment with an investigational new drug within the last 30 days
  • History of a psychological illness or condition such as to interfere with the subject's ability to understand the requirements of the study.
  • Treatment with Vitamin E, Vitamin C, beta carotene, lipoic acid, or other food or herbal supplements within 2 weeks of enrollment (subjects taking multivitamins or other forms of vitamin E and C in doses that do not exceed two times the RDA will not be excluded).

Treatment and study plan

Cranberry Juice

Dietary Supplement

480 ml of double strength cranberry juice daily for four weeks

Primary outcomes

  1. Brachial artery flow-mediated dilation

    Time frame: 1 month

Secondary outcomes

  1. Carotid-femoral pulse wave velocity

    Time frame: 1 month

  2. Markers of inflammation

    Time frame: 1 month

  3. Serum anthocyanins

    Time frame: 1 month

Sponsors and collaborators

Lead sponsor

Boston University

Other

Registry information

Official study title

Long-Term Effects of Cranberry Juice on Endothelial Function in Patients With Coronary Artery Disease

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Nov 6, 2007
Registry last updated
Jun 18, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.