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OpenTrials
Completed

NCT Number: NCT00863135

Effect of CPAP on Blood Pressure in Patients With Sleep Apnea and Refractory Hypertension

The purpose of this study is to determine the effects of CPAP treatment on blood pressure in patients with sleep apnea syndrome (SAS) and refractory arterial hypertension (RAH).

Also, some of the mechanisms mediating SAS and RAH (systemic inflammation, oxidative stress, sympathetic hyperactivity) will be analyzed.

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Key information

Conditions

Obstructive Sleep Apnea Apnea Cardiovascular Diseases Dyssomnias Hypertension Nervous System Diseases Refractory Arterial Hypertension Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders Vascular Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Corporacio Parc Tauli

Sabadell, Barcelona, 08208, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • refractory arterial hypertension and sleep apnea with apnea-hypopnea index over 15

Exclusion criteria

  • excessive sleepiness
  • professional drivers
  • secondary arterial hypertension

Treatment and study plan

CPAP

Device

continuous positive airways pressure

Control

Device

Patients are 3 months without any change in their treatment, and are in the waiting list to come into the CPAP procedure after that time

Primary outcomes

  1. 24 hours blood pressure monitoring

    Time frame: basal and after three months of CPAP treatment

Secondary outcomes

  1. oxidative stress and inflammatory mediators

    Time frame: basal and after three months of CPAP treatment

Sponsors and collaborators

Lead sponsor

Corporacion Parc Tauli

Other

Collaborators

  • Carlos III Health Institute

Registry information

Official study title

Effect of Continuous Positive Airway Pressure (CPAP) Treatment on Blood Pressure in Patients With Sleep Apnea and Refractory Hypertension

Important dates

Study start
2008
Primary completion
2016
Study completion
2016
First posted
Mar 17, 2009
Registry last updated
Feb 9, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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