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Completed

NCT Number: NCT07241507

Effect of Continuous Versus Interrupted Suturing on Wound Dehiscence and Infection After Abdominal Surgery

The goal of this clinical trial is to learn whether the type of suturing technique used to close the abdomen after exploratory laparotomy affects the rate of wound complications. Specifically, the study aims to find out if using interrupted sutures results in fewer cases of wound dehiscence (wound reopening) compared to continuous sutures.

The main question the study seeks to answer is:

Does interrupted suturing reduce the frequency of wound dehiscence compared to continuous suturing in patients undergoing exploratory laparotomy?

Researchers will also observe and compare wound infection rates between the two suturing methods.

About 80 adult patients (18-60 years old) undergoing exploratory laparotomy at the Department of General Surgery, DHQ Teaching Hospital, Dera Ghazi Khan, will take part in this study. Participants will be randomly assigned to one of two groups:

Group A: Continuous abdominal closure using No. 1 Vicryl suture

Group B: Interrupted abdominal closure using No. 1 Vicryl suture

All participants will have their baseline characteristics recorded, including age, gender, obesity, diabetes, and smoking status. The surgical technique and postoperative care will follow the hospital's standard protocols. After surgery, patients will be followed for four weeks with weekly clinical assessments to check for wound infection or wound dehiscence.

The hypothesis is that patients whose abdominal wounds are closed with interrupted sutures will have a lower frequency of wound dehiscence compared to those with continuous sutures.

The findings will help guide surgeons on which abdominal closure method provides better wound healing and fewer postoperative complications.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Allama Iqbal Teaching Hospital, Dera Ghazi Khan

Dera Ghazi Khan, Punjab Province, 32200, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Undergoing exploratory laparotomy
  • Both emergency and elective

Exclusion criteria

  • Patients undergoing second laparotomy or re- laparotomy
  • Patients on steroid therapy (assessed on medical record review)
  • Patients who die within 28-days of surgery

Treatment and study plan

Continuous suturing

Procedure

After an exploratory laparotomy continuous suturing using a single thread of Vicryl No. 1 will be used to stitch the incision's fascial layer together, 1 cm distance from wound edges and between each stitch, creating a line of even tension across the wound.

Interrupted suturing

Procedure

After an exploratory laparotomy, interrupted suturing using a single thread of Vicryl No. 1 will be used to stitch the incision's fascial layer together, 1 cm distance from wound edges and between each stitch. A knot will be tied after each suture is passed through the tissue, and each stitch will be secured with its own knot.

Primary outcomes

  1. Wound Dehiscence

    Time frame: From enrollment to 28-days of operation

    A partial or total separation of previously approximated wound edges, on clinical examination of surgical wound.

Other outcomes

  1. Surgical Wound Infection

    Time frame: From enrollment to 28-days after operation

    Presence any features of erythema, pain, pus discharge on examination of surgical wound and new onset fever (> 98.60F)

Sponsors and collaborators

Lead sponsor

Allama Iqbal Teaching Hospital

Other Gov

Registry information

Official study title

Frequency of Wound Dehiscence and Wound Infection in Continuous Versus Interrupted Suturing for Abdominal Closure in Exploratory Laparotomy

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Nov 21, 2025
Registry last updated
Nov 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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