Effect of Cold Atmospheric Plasma on Malassezia Folliculitis

Malassezia folliculitis is a common disease of young and middle-aged people. It is an inflammatory disease caused by Malassezia infection. Generally, Topical or systemic use of antifungal drugs are the first choice for treatment but sometimes are limited due to adverse drug reactions and drug resistance. Cold atmospheric plasma has an inhibitory or killing effect on pathogenic microorganisms including fungi and has no obvious adverse damage to normal tissues. The investigators conduct this randomized controlled trial to study the effect of cold atmospheric plasma on Malassezia folliculitis, and evaluate its effectiveness and safety for Malassezia folliculitis. All data are recorded and compared after the end of the experiment.

Inclusion criteria

• Patients are clinical presentation of Malassezia folliculitis in seborrheic areas.
• The diagnoses are mycologically verified by experienced laboratory technicians.
• Participants must be informed of the investigational nature of this study and be willing to provide written informed consent.

Exclusion criteria

• Combined with other serious systemic diseases.
• History of topical corticosteroids within 2 weeks or history of systemic corticosteroids within 1 month.
• History of immunosuppressive drugs within 1 month.
• History of topical antifungal medication within 2 weeks or systemic antifungal medication within 3 months.
• Pregnant and lactating women.