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NCT Number: NCT07677826

Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation

This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.

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Key information

Conditions

Depigmentation Treatment Depigmentation Hypopigmentation Pigmentation Disorders Skin Diseases Skin and Connective Tissue Diseases Vitiligo

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of dental medicine for girls? ALAZHAR University, Cairo, egypt

Nāşir, Egypt

Location status: Recruiting

Location contact

Nora Abdelgawad Associate professor, Phd

CONTACT

[email protected]

+×01019407891

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systemically healthy patient of both genders aged from 18-45 years.
  • Presence of bilateral physiologic gingival pigmentation in the anterior maxillary or mandibular region DOPI grades III-IV only.
  • Good oral hygiene.
  • Thick gingival phenotype.

Exclusion criteria

  • Patient clinically diagnosed with periodontitis.
  • Pregnant or lactating females.
  • Patient with previous treatment of gingival hyperpigmentation.
  • History of hypersensitivity to any study material.
  • Patients who are active or previous smokers.

Treatment and study plan

Surgical depigmentation

Procedure

Surgical gingival depigmentation performed using the conventional scalpel technique. The pigmented gingival epithelium is surgically removed under local anesthesia to eliminate melanin pigmentation and improve gingival esthetics.

Coenzyme Q10

Dietary Supplement

Coenzyme Q10 administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation.

Vitamin C

Dietary Supplement

Vitamin C administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival depigmentation.

Surgical Gingival Depigmentation Coenzyme Q10 Vitamin C

Dietary Supplement

Coenzyme Q10 and vitamin c administered according to the study protocol following surgical gingival depigmentation to evaluate its effect on wound healing and gingival repigmentation.

Primary outcomes

  1. Change in gingival pigmentation intensity using the Dummett Oral Pigmentation Index (DOPI). The DOPI scale from 0 to 3, where:0 = No clinical pigmentation ,1 = Mild pigmentation , 2 = Moderate pigmentation 3 = Heavy pigmentation

    Time frame: 1 week, 1 month and 3 months. ,6 months

    Change in gingival pigmentation intensity that measured by using a standardized gingival pigmentation index (DOPI)

Study contacts

Contact information is provided by the study sponsor or research team.

nora abdelgawad abdelgawad, phd

CONTACT

021019407891

nora abdelgawad associate professor, phd

CONTACT

[email protected]

+201019407891

Sponsors and collaborators

Lead sponsor

Al-Azhar University

Other

Registry information

Official study title

Ffect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation a Randomized Clinical Study

Acronym: Effect of Coe

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 1, 2026
Registry last updated
Jul 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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