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OpenTrials
Completed

NCT Number: NCT00420901

Effect of Chronic PDE5-Inhibition on Endothelial Function in Diabetics

chronic PDE5-Inhibition improves endothelial function in diabetics

Completed

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Key information

Conditions

Diabetes Behavior Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Inhibition, Psychological Metabolic Diseases Nutritional and Metabolic Diseases

Age range

35 year–75 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 3

Primary location

San Raffaele EUR

Roma, 00144, Italy

About this study

Evaluation of endothelial function at baseline and after chronic administration of sildenafil in male subjects with diabetes

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • type 2 diabetes
  • males

Exclusion criteria

  • females, nitrate use, PDE5-Inhibitors intolerance

Treatment and study plan

Sildenafil

Drug

Primary outcomes

  1. Endothelial function responders - Improvement in endothelial function

Secondary outcomes

  1. Changes in vascular inflammatory markers

Sponsors and collaborators

Lead sponsor

IRCCS San Raffaele

Other

Registry information

Official study title

Effect of Chronic Administration of Sildenafil on Endothelial Function in Men With Diabetes

Important dates

Study start
1999
Study completion
2000
First posted
Jan 11, 2007
Registry last updated
Jan 11, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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