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OpenTrials
Completed

NCT Number: NCT03547102

Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

Effect of 8 weeks of cherry concentrate supplementation on cognitive function and brain perfusion in healthy older adults

Completed

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Key information

Conditions

Healthy

Age range

60 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

The investigators will perform a double blind, randomised controlled study to determine whether cherry polyphenols improve peripheral vascular function and cerebral perfusion resulting in improved task related brain activation and cognitive function. 30 healthy elderly men and women 60-85y years will be recruited to complete 8-week supplementation with MC concentrate or an isoenergetic cherry placebo concentrate. Participants will be pair matched for age, sex, and cognitive function (Adenbrooke's Cognitive Examination III, ACE-III) and then randomised using a sealed envelope system to receive either placebo or cherry.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • physically inactive consuming 5 or less portions of fruit per day Addenbrookes cognitive examination III score >88

Exclusion criteria

  • physically active consuming more than 5 portions of fruit per day Addenbrookes cognitive examination III score <88 Contraindications for MRI

Treatment and study plan

Cherry concentrate

Dietary Supplement

Placebo concentrate

Dietary Supplement

Primary outcomes

  1. Brain perfusion

    Time frame: Change from baseline to 8 weeks supplementation

    Arterial spin labelling using MRI, measure will be reported as ml/min

Secondary outcomes

  1. Cognitive function

    Time frame: Change from baseline to 8 weeks supplementation

    Battery of cognitive function tasks assessing executive function, global cognitive function score will be reported

  2. Brain activation (fMRI)

    Time frame: Change from baseline to 8 weeks supplementation

    fMRI using a hippocampal biased task

  3. Plasma nitrite concentration

    Time frame: Change from baseline to 8 weeks supplementation

    Plasma sample analysed via chemiluminescence technique

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Registry information

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Jun 6, 2018
Registry last updated
Jun 26, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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