Effect of CGF on Postoperative Pain After Third Molar Surgery

The purpose of this study is to evaluate the effects of concentrated growth factor (CGF) on pain after bilateral impacted third molar surgery and to determine its contribution to the healing process.

The main question it aims to answer is:

Is CGF effective on reducing the pain in impacted third molar surgery? Researchers compare the pain on the CGF-applied and CGF free sides after impacted third molar surgery. Postoperative pain is assessed using the Visual Analogue Scale. TThe postoperative outcomes including pain are clinically assessed at different-time intervals (1-7 days).

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Key information

Conditions

Oral Complication Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ege University Faculty of Dentistry

Izmir, Bornova, 35040, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with bilateral, symmetrical, bone-retained (vertical, mesioangular, horizontal) impacted wisdom teeth in the mandible, regardless of gender
Patients without any systemic disease
Patients who have been informed about the duration, purpose and requirements of the study and who have signed the informed consent form voluntarily.

Exclusion criteria

Having a disease affecting general health that requires the application of prophylactic antimicrobial agents
Having a systemic viral, fungal or bacterial infection
Patients with acute or chronic maxillary sinusitis
Suspected or diagnosed pregnancy and nursing mothers
Patients with heart and vascular diseases
Patients with liver disease, haematological disease and neoplastic disease
Patients who have recently received anti-inflammatory therapy
Patients with chronic medication use (antihistamines, NSAIDs, steroids and antidepressants)
Patients predisposed to psychotic or psychopathic tendencies
Patients with rheumatic diseases, blood diseases, diabetes mellitus
Patients at cardiological risk of infective endocarditis
Patients under antibiotic pressure

Treatment and study plan

Concentrated Growth Factor

Other

Bilaterally impacted third molar of the patients are removed surgically and concentrated growth factor is placed in one of the extraction sockets.

non-CGF

Other

The other extraction socket is left empty for control purposes.

Primary outcomes

Postoperative pain on CGF-applied and CGF free sides in bilateral impacted third molar surgery

Time frame: The postoperative outcomes including pain are clinically assessed at different-time intervals (1st, 2nd, 3rd, 4th, 5th, 6th and 7th days).

The primary outcome measure is postoperative pain on CGF-applied and CGF free sides in bilateral impacted third molar surgery. Postoperative pain is assessed using the Visual Analogue Scale (VAS). Patients are asked to mark the pain they felt on the scale (10 cm long line) on the (1-7) days after the operation. The end of the line indicates unbearable pain, the beginning indicates no pain.

Sponsors and collaborators

Lead sponsor

Ege University

Other

Registry information

Official study title

The Power of Concentrated Growth Factor: A New Era in Pain Management in Third Molar Surgery

Important dates

Study start: 2017
Primary completion: 2018
Study completion: 2018
First posted: Apr 9, 2025
Registry last updated: Apr 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed