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NCT Number: NCT07369518

Effect of Ceftazidime-Avibactam on Carbapenemase-Producing Klebsiella Pneumoniae

Specimen Collection : Clinical specimens included blood, urine, bronchoalveolar lavage fluid, wound, peritoneal fluid, and tracheal aspirate obtained from patients with suspected bacterial infections collected in dry sterile well-closed plastic cups.

Bacterial identification by Gram stain, culture and biochemical rections

* analysisThe resistance pattern of the isolates will be detected by disc diffusion method. * phenotypic detection of carbapenemases. • Detection of carbapenem resistance genes (KPC, VIM, IMP, OXA-48, NDM) by conventional PCR.

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Key information

Conditions

ISOLATION OF KLEB. by Culture on macConkey Agar Antibiotic Sensitivity Testing of Different Antibiotics According to Clsi 25 Detection of Resistance Gene in Isolates Using Conventional Pcr Detection of Some Virulence Genes Using Conventional Pcr Effect of Ceftazidime-Avibactam on Carbapenemase-Producing Klebsiella Pneumoniae

Sex eligibility

All sexes

Study type

Observational

Primary location

Faculty of medicine Sohag University

Sohag, Egypt

About this study

Carbapenem-resistant Enterobacterales (CRE) poses an urgent global public health threat, with more than 1,100 documented deaths, as reported in a 2019 antibiotic resistance publication by the U.S. Centers for Disease Control and Prevention.

Carbapenem-resistant Enterobacterales, including carbapenem-resistant Klebsiella pneumoniae (CRKP), is associated with higher mortality compared with infections caused by carbapenem-susceptible Enterobacterales infections Specimen Collection : Clinical specimens included blood, urine, bronchoalveolar lavage fluid, wound, peritoneal fluid, and tracheal aspirate obtained from patients with suspected bacterial infections collected in dry sterile well-closed plastic cups.

Bacterial identification by Gram stain, culture and biochemical rections

  • analysisThe resistance pattern of the isolates will be detected by disc diffusion method.
  • phenotypic detection of carbapenemases. • Detection of carbapenem resistance genes (KPC, VIM, IMP, OXA-48, NDM) by conventional PCR.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Infections caused by klebsiella pneumoniae like skin infections, chest infections, surgical site infections, and urinary tract Infections.-

Exclusion criteria

  • Infections caused by any organisms other than klebsiella pneumoniae and carbapenem resistant klebsiella pneumoniae by mechanism other than carbapenemases production.

Treatment and study plan

. - Genotypic detection of carbapenemase genes by conventional PCR.

Genetic

Specimen Collection : Clinical specimens included blood, urine, bronchoalveolar lavage fluid, wound, peritoneal fluid, and tracheal aspirate obtained from patients with suspected bacterial infections collected in dry sterile well-closed plastic cups. Bacterial identification by Gram stain, culture and biochemical rections - analysisThe resistance pattern of the isolates will be detected by disc diffusion method. - phenotypic detection of carbapenemases. • Detection of carbapenem resistance genes (KPC, VIM, IMP, OXA-48, NDM) by conventional PCR.

Primary outcomes

  1. 1 ISOLATION OF KLEB. by culture on macConkey agar

    Time frame: 6 months from January to may

  2. Antibiotic sensitivity testing of different antibiotics according to clsi 25

    Time frame: 6 months from January to may

  3. Effect of Ceftazidime-Avibactam on Carbapenemase-Producing Klebsiella Pneumoniae

    Time frame: 6 months from January to may

  4. Detection of resistance gene in isolates using conventional pcr

    Time frame: 6 months from June to December

  5. Detection of some virulence genes using conventional pcr

    Time frame: 6 months from June to December

Study contacts

Contact information is provided by the study sponsor or research team.

Walaa Ismael, Demonstrator

CONTACT

[email protected]

+20114 8736091

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Effect of Ceftazidime-Avibactam Against Carbapenemase-Positive Klebsiella Pneumoniae Causing Health Care-Associated Infections

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jan 27, 2026
Registry last updated
Jan 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.