Skip to main content
OpenTrials
Completed

NCT Number: NCT03105089

Effect of Cardiac Preconditioning Upon the Inotrope Score

preconditioning of no debate has a valuable effect upon myocardial protection . pre-cardiopulmonary bypass pre-conditioning , suspected to have a role upon postoperative inotropic support

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Open Heart Surgery Preconditioning

Age range

16 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Emad Zarief Kamel Said

Asyut, 71111, Egypt

About this study

Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be ( ischemic ;pharmacologic or Physical) Pharmacological pc may be induced by variable agents e.g. (Sevoflurane ;isoflorane, opioids etc ) Ischemic pc includes local ;remote and the idea is temporary interruption of blood supply to the organ so that liberation of protective mediators occurs The liberated mediators have favorable effects not only upon the myocardium But ;it extend to protect other organs against inflammatory activation ;ischemia reperfusion injury Inotropic score IS is already an evident predictor of postoperative cardiac mobidity and mortality

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patient
  • valve replacement surgery
  • ASA grade 2 or 3

Exclusion criteria

  • emergency surgery
  • - poor general conditions
  • impaired hepatic or renal function
  • peripheral vascular disease
  • patient refusal

Treatment and study plan

Ischemic preconditioning

Procedure

) ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles

Primary outcomes

  1. inotropic score

    Time frame: 48 hours

Secondary outcomes

  1. renal function

    Time frame: 2 dyas

    serum creatinine

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Impact of Variable Types of Preconditioning Upon the Inotrope Score in Adult Patients, Undergoing Cardiac Surgery

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Apr 7, 2017
Registry last updated
Oct 30, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.