Effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain and Bacterial Reduction in Mandibular Premolars With Necrotic Pulps. .

This study aims to assess the effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain and Bacterial Reduction in Mandibular Premolars with Necrotic Pulps.

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Key information

Conditions

Intervention

Age range

20 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Systematically healthy patient (ASA I, II).
Age between 20 and 55 years
Male or female.
Mandibular premolar teeth having single canals diagnosed with pulp necrosis with asymptomatic apical periodontitis.
Radiographic examination using Digora intraoral periapical sensor plate and software showing mandibular premolars with (0-2 mm) periapical radiolucency.

Exclusion criteria

Medically compromised patients having significant systemic disorders. (ASA III or IV).
History of intolerance to NSAIDS.
Teeth with:

Immature roots
Vital pulp tissues.
Association with swelling.
Acute peri-apical abscess or acute exacerbation of a chronic abscess.
Mobility Grade II or III.
Previously accessed or endodontically treated
Deep periodontal pockets more than 4 mm
Vertical root fractures, coronal perforation, calcification, and external or internal root resorptions.
Patients who could not interpret the NRS.
Patients with diabetes, immune-compromising, and immunosuppression disease and pregnant women were, also, excluded.

Treatment and study plan

Calcium Hypochlorite as Root Canal Irrigant

Other

Calcium Hypochlorite used as root canal irrigant during chemo-mechanical preparation

Primary outcomes

Effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain in Mandibular Premolars with Necrotic Pulps.

Time frame: measured at 6, 12, 24, 48 hours after single visit treatment

measuring tool: Numerical Rating Scale (NRS). Unite of measurement: Categorical None 0 Mild 1-3 Moderate 4-6 Severe 7-10 Time of measurements: At 6, 12, 24, 48- hours post-treatment.

Secondary outcomes

Effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Bacterial Reduction in Mandibular Premolars with Necrotic Pulps.

Time frame: T0=Baseline immediate after access preparation . T1=Post-instrumentation. T1(within an hour)

Intracanal bacterial load reduction will be determined by bacterial counting using agar culture technique after root canal preparation (CFUs/ml), The growth will be semi quantitatively determined as very heavy, heavy, moderate, sparse and very sparse depending on the CFU ranging from >100,000,˂100,000,˂10,000,˂1,000, ˂100 colony forming unit per 1 ml BHI respectively.
Number of analgesic tablets taken by the patient after endodontic treatment

Time frame: Up to 48 hours postoperative.

Number of analgesic tablets taken by the patient after endodontic treatment Up to 48 hours postoperative.

Measuring tool: counting Measurment unite: numerical.

Study contacts

Contact information is provided by the study sponsor or research team.

Youmna Yassen Youmna Yassen, pds

CONTACT

[email protected]

01146877037

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effect of Calcium Hypochlorite Versus Sodium Hypochlorite as Root Canal Irrigants on Postoperative Pain and Bacterial Reduction in Mandibular Premolars With Necrotic Pulps. A Randomized Clinical Trial.

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Jul 19, 2024
Registry last updated: Jul 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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