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NCT Number: NCT06842290

Effect of Botulinum Toxin a Injection in Treatment of Recession RT1 and RT2

The goal of this study type: clinical trial] is to learn the effect of Botulinum Toxin _A injection in treatment of RT1andRT2 Gingival recession in lower anterior teeth .

Primary outcome is keratinzed tissue width. Researchers will compare Coronally Advanced flap with De-epithelized free gingival graft and Botulinum toxin-A injection in Mentalis muscle with coronally advanced flap with De-epithelized free gingival graft alone .

The outcome will be measured at baseline, after 3 months and after 6 mobths _medical history

* 3 mm horizontal incisions, then two vertical incisions * deepitheliztion of anatomical papillae * superficial and deep incisions * harvesting DFGG * Suturing * BOTOX injection

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Key information

Conditions

Gingival Recession Gingival Diseases Mouth Diseases Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Single or multiple RT1, RT2 GR patient
  • patients ≥18 years
  • systemically healthy, full mouth plaque score, full mouth bleeding score ≤ 15% after phase I therapy
  • clinical indication and/or patient request for recession coverage
  • well motivated patients, maintaining oral hygiene throughout study

Exclusion criteria

  • Pregnant or lactating women
  • Smokers' patients
  • Teeth with cervical restorations/abrasion.
  • Patients had a systemic condition affect blood components and healing

Treatment and study plan

Botulinum toxin-A injection

Procedure

Botulinum toxin-A Injection Mentalis muscle in lower anterior teeth

coronally advanced flap

Procedure

Coronally Advanced Flap andDe-epithelized Free Gingival Graft

Primary outcomes

  1. Keratinized tissue width

    Time frame: Measured at baseline ,3months ,6 months

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effect of Botulinum Toxin -A Injection in Mentalis Muscle with Coronally Advanced Flap and De-epithelized Free Gingival Graft in Treatment of RT1 , RT2 Gingival Recession _Randomized Control Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 24, 2025
Registry last updated
Feb 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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