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NCT Number: NCT05596474

Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue

The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question:

Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement?

Does red light therapy improve forearm muscle endurance compared to a sham light exposure?

Does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?

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Key information

Conditions

Health Care Utilization Behavior Health Behavior Healthy Aging Patient Acceptance of Health Care Treatment Adherence and Compliance

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wake Forest Univesity

Winston-Salem, North Carolina, 27106, United States

Location status: Recruiting

Location contact

Andrew D Wells, Ph.D.

CONTACT

[email protected]

336-758-5837 ext. 2156

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Self-reports performing at least 30 minutes of light to moderate intensity physical activity 3 times per week for the last three months

Exclusion criteria

  • Currently smoke
  • Have smoked within the last 6 months
  • Are taking taking supplements known to increase blood nitrate levels
  • Have a known kidney disease
  • Have a known liver disease
  • Have a known thyroid condition
  • Have a known gastritis condition
  • Are taking medications that are known to cause complications with nitrate supplementation
  • Have known or reported joint pain within the dominant hand

Treatment and study plan

Beet-root juice

Dietary Supplement

Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing.

Other names: Beet it Sport

red-light therapy

Radiation

Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes.

Other names: MitoMIN

Placebo

Dietary Supplement

Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing.

sham light

Radiation

Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes.

Primary outcomes

  1. Total forearm work performed

    Time frame: During the forearm exercise fatigue protocol lasting up to 45 minutes

    Work is the product of the number of times the forearm is activated multiplied by the amount of force produced by the forearm in kilograms.

Secondary outcomes

  1. Forearm endurance

    Time frame: During the forearm exercise fatigue protocol lasting up to 45 minutes

    The duration of time the participant takes to complete the forearm fatigue protocol

  2. Intermuscular coordination

    Time frame: During the forearm exercise fatigue protocol lasting up to 45 minutes

    Surface electromyography measurements of muscle activity

Study contacts

Contact information is provided by the study sponsor or research team.

Andrew D Wells, Ph.D.

CONTACT

[email protected]

(336) 758-5837 ext. 2156

Sponsors and collaborators

Lead sponsor

Wake Forest University

Other

Registry information

Official study title

Application of Beet-root Juice Supplementation and Photobiomodulation Treatment on Forearm Muscle Fatigue in Older Adults

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Oct 27, 2022
Registry last updated
Mar 20, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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