Completed

NCT Number: NCT03230214

Effect of Bacterial Translocation on Haemodynamic and Coagulation Parameters During Liver Transplantation

The present study is to demonstrate the effect of the presence of bacterial translocation detected by bacterial deoxyribonucleic acid (bactDNA) in blood and ascites using the polymerase chain reaction (PCR) on some haemodynamic and coagulation parameters during a liver transplant procedure.

Completed

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Key information

Conditions

Effect of Bacterial Translocation

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Elmoasah Hospital

Alexandria, Egypt

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with liver failure undergoing liver transplantation

Exclusion criteria

Age less than 18 years;
Active overt infection;
Patients on oral or systemic anticoagulation or with known coagulopathic disorders apart from those caused by liver failure (eg.: Protein C or S deficiency, congenital platelet disorders and congenital coagulation disorders…etc);
Patients undergoing re-transplantation.

Treatment and study plan

PCR for bacterial translocation

Diagnostic Test

samples taken from the blood and ascites of patients to search for bacterial DNA

Primary outcomes

change in the mean arterial blood pressure

Time frame: at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase
antifactor X activity

Time frame: at the beginning of surgery
change in the heart rate

Time frame: at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase
change in the cardiac output

Time frame: at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase

Sponsors and collaborators

Lead sponsor

Alexandria University

Other

Registry information

Official study title

Effect of Bacterial Translocation on Haemodynamic and Coagulation Parameters During a Liver Transplantation

Important dates

Study start: 2017
Primary completion: 2017
Study completion: 2017
First posted: Jul 26, 2017
Registry last updated: Jan 17, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.