Effect of Atorvastatin on Fractional Flow Reserve in Coronary Artery Disease

The patients who have intermediate CAD (30-80% diameter stenosis by visual estimation) with FFR≥0.80, or nonculprit coronary artery disease with FFR≥0.8 after culprit coronary artery disease intervention will be enrolled. FFR, IVUS(optional) and index of microcirculatory resistance (IMR) should be performed simultaneously. Atorvastatin 20mg is a starting dose, then up-titration will be done twice within each 4~6weeks until LDL target goal (① LDL<70mg/dl, or ② statin naive: >50% reduction from baseline LDL, current statin user: >30% reduction from baseline LDL). First titration will be atorvastatin 40mg, second will be atorvastatin 80mg. If patients have any adverse effect on atorvastatin, the dose of atorvastatin can be adjusted by investigator's decision. Official clinical follow-up except visit for statin dose titration will occur at 1, 12 months after index procedure. Follow-up coronary angiography, FFR,IMR,and IVUS(optional) will be performed 12 months after index procedure.

Inclusion criteria

• patient > 18 years of age and willing to participate
• patients who have stable intermediate CAD(30-80% diameter stenosis by visual estimation) on angiography with FFR≥0.8,or who have nonculprit CAD which is not planned revascularization
• Signed written Informed Consent

Exclusion criteria

• Patients who are in cardiogenic shock
• Patients with LVEF<35%
• Patients with left main disease, restenotic, bypass grafted lesions
• Patients with platelet count < 100,000 cell/mm3
• Patients who have co-morbidity which reduces life expectancy to one year
• Patients who have a history of stroke or transient ischemic attack within 6 months
• Patients who are planned discontinuation of medication due to surgery
• Patients with known adverse reaction to HMG CO-A reductase therapy (statins)
• Patients with liver disease (elevation of AST or ALT more than 2 times)
• Patient with creatinine > 2.0 mg/dL
• Pregnant women and women of childbearing potential who intend to have children during the duration of the trial
• Patients who consistently must take drugs affecting lipid levels in blood except the investigational product