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OpenTrials
Completed

NCT Number: NCT00610870

Effect of Atorvastatin Administration Before Primary Percutaneous Coronary Intervention

The purpose of this study to determine whether statin pretreatment decrease myocardial infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.

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Key information

Conditions

Angioplasty, Transluminal, Percutaneous Coronary

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Samsung Medical Center

Seoul, 135-710, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Presence of chest pain for more than 30 minutes but less than 12 hours after symptom onset
  • ST segment elevation more than 1 mm in two or more contiguous leads or presumably a new onset left bundle branch blockage

Exclusion criteria

  • Cardiogenic shock
  • History of myocardial infarction
  • Chronic liver disease
  • Previous or current statin use

Treatment and study plan

atorvastatin

Drug

atorvastatin 80mg/day before primary coronary intervention

Primary outcomes

  1. Myocardial infarct size by SPECT

    Time frame: between 5 and 14 days after acute myocardial infarction

Secondary outcomes

  1. Myocardial infarct size measured by contrast-enhanced MRI

    Time frame: within 14 days after acute myocardial infarction

  2. Myocardial blush grade after the procedure

    Time frame: immediate after procedure

  3. complete ST resolution

    Time frame: at 60 minutes after the procedure

  4. major adverse cardiac events related to left ventricular dysfunction (death, new-onset sustained hypotension or heart failure, and hospital readmission for left ventricular dysfunction)

    Time frame: at 6 months after the procedure

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Effect of Atorvastatin Administration Before Primary Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction

Important dates

Study start
2007
Primary completion
2009
Study completion
2009
First posted
Feb 8, 2008
Registry last updated
Mar 3, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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