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NCT Number: NCT07653529

Effect of Antigravity Treadmill Training on Cardiorespiratory Fitness and Lower Limb Function in Incomplete Spinal Cord Injury

This study aims to investigate the effect of locomotor training using an antigravity treadmill on cardiorespiratory fitness and lower limb function in patients with incomplete spinal cord injury.

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Key information

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Sixty patients with incomplete spinal cord injury will be randomly assigned into two equal groups: the experimental group and the control group. Participants will be adults diagnosed with incomplete spinal cord injury classified as ASIA C or D. The experimental group will receive locomotor training using an antigravity treadmill in addition to conventional physiotherapy rehabilitation for 12 weeks. The control group will receive conventional physiotherapy rehabilitation only. The antigravity treadmill training program will be performed three sessions per week. Training intensity and body-weight support will be progressively adjusted according to patient tolerance and functional improvement.

Cardiorespiratory fitness will be evaluated using cardiopulmonary exercise testing and functional endurance assessments. Lower limb function will be assessed using gait and balance outcome measures.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Incomplete spinal cord injury (ASIA C or D)

  • Injury duration more than 3 months
  • Ability to stand with or without assistance
  • Medically stable condition

Exclusion criteria

  • Complete spinal cord injury
  • Severe cardiopulmonary disorders
  • Severe osteoporosis or fractures
  • Severe cognitive impairment
  • Other neurological disorders affecting gait

Treatment and study plan

Antigravity Treadmill for gait training

Device

Antigravity treadmill for gait training

gait training and balance exercise

Other

gait training between Parallel bar Balance Exercise

Primary outcomes

  1. Cardiorespiratory fitness

    Time frame: At base line and 12 weeks

    Cardiopulmonary fitness will be measured by Cardiopulmonary Exercise Testing (CPET) to assess the integrated function of the cardiovascular, pulmonary, and muscular systems during exercise.

    The gold-standard parameter obtained from CPET is:

    VO₂max VO₂max: Maximum rate of oxygen consumption achieved during maximal exercise. Units: mL/kg/min

  2. Lower Limb Function

    Time frame: At base line and 12 weeks

    Lower limb function will be measured by 10-Meter Walk Test (10MWT) is a simple and reliable measure of walking speed,

    Assesses:

    Gait speed Procedure Mark a 10-meter walkway.

    The patient will walks at:

    Comfortable/self-selected speed (usual gait speed) Walking Speed (m/s)= Distance (m) /Time (s)

Study contacts

Contact information is provided by the study sponsor or research team.

Saher Lotfy Elgayar, phd

CONTACT

[email protected]

00962786757649

Sponsors and collaborators

Lead sponsor

Middle East University

Other

Registry information

Official study title

Effect of Antigravity Treadmill Locomotor Training on Cardiorespiratory Fitness and Lower Limb Function in Patients With Incomplete Spinal Cord Injury

Acronym: Antigravity

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 17, 2026
Registry last updated
Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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