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NCT Number: NCT02191371

Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation

One-lung ventilation during thoracic surgery may affect systemic oxygenation and peripheral microcirculation by hypoxic pulmonary vasoconstriction. Both intravenous and inhalational anesthetics can be used during one-lung ventilation. However, there is still a controversy which anesthetic would be more appropriate during one-lung ventilation in the perspective of oxygenation and microcirculation. The investigators hypothesized that intravenous and inhalational anesthetics may affect oxygenation and microcirculation differently during one-lung ventilation.

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Key information

Conditions

Mechanical Ventilation Complication

Age range

20 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital

Seoul, 110-744, South Korea

About this study

Patients undergoing thoracic surgery including one-lung ventilation will be randomized to receive intravenous (propofol) or inhalational (desflurane) anesthetic.

Systemic oxygenation can be evaluated by measuring partial pressure of oxygen in arterial blood analysis. Microcirculatory parameters can be obtained from vascular occlusion test. Among those parameters, recovery slope during vascular occlusion test is known to reflect recruitment of microvasculature in response to hypoxic or ischemic insult. In this study, we will compare arterial partial pressure of oxygen and recovery slope during one-lung ventilation between propofol and desflurane group.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • undergoing thoracic surgery including one-lung ventilation

Exclusion criteria

  • refuse to enroll
  • BMI over 30 kg/m(2)
  • severe obstructive or restrictive lung disease
  • preoperative supplemental oxygen, intubated, or mechanical ventilatory support
  • preoperative arterial partial pressure of oxygen < 60 mmHg
  • pregnancy
  • history of coronary artery disease
  • preoperative continuous infusion of vasopressor or inotropes
  • cannot undergo vascular occlusion test: anatomical abnormality of both arms, severe peripheral vascular disease, presence of A-V fistula

Treatment and study plan

Propofol

Drug

Patients are randomized to receive intravenous anesthetic (propofol) or inhalational anesthetic (desflurane) as a maintenance anesthetic.

Other names: propofol (Fresofol(R)2 MCT 2%, Fresenius Kabi)

Desflurane

Drug

Patients are randomized to receive intravenous anesthetic (propofol) or inhalational anesthetic (desflurane) as a maintenance anesthetic.

Other names: desflurane (Suprane(R), Baxter Healthcare)

Primary outcomes

  1. arterial partial pressure of oxygen

    Time frame: 30 min after one-lung ventilation

    Primary outcome is arterial partial pressure of oxygen 30 min after one-lung ventilation during thoracic surgery in propofol and desflurane groups.

Secondary outcomes

  1. recovery slope

    Time frame: 30 min after one-lung ventilation

    Secondary outcome is recovery slope measured by vascular occlusion test 30 min after one-lung ventilation during thoracic surgery in propofol and desflurane groups.

Other outcomes

  1. blood pressure

    Time frame: 30 min after one-lung ventilation

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Jul 16, 2014
Registry last updated
Oct 13, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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