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OpenTrials
Completed

NCT Number: NCT00693199

Effect of Amlodipine Monotherapy or Combined With Terazosin on Lower Urinary Tract Symptoms and Hypertension

The aim of this study was to investigate the efficacy and safety of low dose amlodipine alone, or combined with low dose terazosin in male patients with both lower urinary tract symptoms and hypertension.

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Key information

Conditions

Lower Urinary Tract Symptoms Cardiovascular Diseases Essential Hypertension Hypertension Pathological Conditions, Signs and Symptoms Signs and Symptoms Urological Manifestations Vascular Diseases

Age range

50 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Biomedicine Inistitute of Anhui Medical University

Hefei, Anhui, 230032, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men 50 years or older
  • with LUTS [defined as International Prostate Symptom Score (IPSS) >= 10].
  • Stage 1 or 2 essential hypertension (SBP >= 140 mm Hg and < 180 mm Hg and/or DBP >= 90 mm Hg and < 110 mm Hg)

Exclusion criteria

  • A history of postural hypotension
  • Secondary hypertension
  • Prostate cancer
  • Prostate surgery or other intervention
  • Use of any agents to influence the LUTS symptoms in the last 4 weeks
  • Other severe diseases

Treatment and study plan

Amlodipine

Drug

amlodipine 5mg once daily for 28 days

Terazosin

Drug

terazosin 2 mg once daily for 28 days

amlodipine plus terazosin

Drug

amlodipine 5 mg plus terazosin 2 mg once daily for 28days

Primary outcomes

  1. The primary efficacy outcomes were reductions in blood pressure and International Prostate Symptoms Score (IPSS) and sub-scores.

    Time frame: 28th day after treatment

Sponsors and collaborators

Lead sponsor

Anhui Medical University

Other

Collaborators

  • Peking University First Hospital
  • The University of Science and Technology of China

Registry information

Important dates

Study start
2006
Primary completion
2006
Study completion
2006
First posted
Jun 6, 2008
Registry last updated
Aug 8, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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