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Completed

NCT Number: NCT02823249

Effect of Amino Acids and Sugar Alcohols on Satiation Peptides and Activation of Specific Brain Regions

With this study the investigators investigate the effects of amino acids (tryptophan, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms and brain activation.

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Key information

Conditions

Endocrine System Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Basel

Basel, Canton of Basel-City, 4031, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy normal weight subjects with a body-mass index of 19.0-24.9
  • Healthy obese subjects with a body-mass index of > 30
  • Normal eating habits (no diets; no dietary changes; no special dietary habits such as vegetarian/vegan)
  • Age 18-40 years
  • Stable body weight for at least three months

Exclusion criteria

  • Smoking
  • Substance abuse
  • Regular intake of medications (except for oral contraceptives)
  • Medical or psychiatric illness
  • History of gastrointestinal disorders
  • Food allergies
  • Pregnancy, breast feeding
  • Body piercings that cannot be removed
  • History of claustrophobia
  • Left-hander

Treatment and study plan

1.56 g L-Tryptophan

Dietary Supplement

1.56 g L-Leucine

Dietary Supplement

50 g Xylitol

Dietary Supplement

75 g Erythritol

Dietary Supplement

75 g Glucose

Dietary Supplement

tap water

Dietary Supplement

Mixed liquid meal (Ensure Plus®; 17% protein, 29% fat and 54% carbohydrate)

Dietary Supplement

Nasogastric tube

Device

Primary outcomes

  1. Effect of aminoacids on cerebral blood flow measured by functional brain MRI

    Time frame: changes from baseline to one hour after treatment

  2. Effect of sugar alcohols on cerebral blood flow measured by functional brain MRI

    Time frame: changes from baseline to one hour after treatment

Secondary outcomes

  1. Measurement of Plasma Glucose concentrations

    Time frame: changes from baseline to three hours after treatment

  2. Measurement of Plasma Insulin concentrations

    Time frame: changes from baseline to three hours after treatment

  3. Measurement of Plasma cholecystokinin concentrations

    Time frame: changes from baseline to three hours after treatment

  4. Measurement of Plasma Glucagon-like Peptide (GLP-1) concentrations

    Time frame: changes from baseline to three hours after treatment

  5. Measurement of Plasma PYY concentrations

    Time frame: changes from baseline to three hours after treatment

  6. Measurement of Plasma ghrelin concentrations

    Time frame: changes from baseline to three hours after treatment

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Official study title

Effect of Amino Acids and Sugar Alcohols on Release of Satiation Peptides and Activation of Specific Brain Regions in Normal Weight and Obese Subjects

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Jul 6, 2016
Registry last updated
Feb 28, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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