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OpenTrials
Completed

NCT Number: NCT03319147

Effect of Amino Acid on Muscle Damage

The primary objective is to determine the impact of essential amino acids on integrated muscle protein synthesis over 4 days after resistance exercise.

In addition, the secondary objective is to determine the effect of essential amino acids on satellite cell regulation and inflammatory responses during this prolonged recovery period.

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Key information

Conditions

Healthy Behavior Motor Activity

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Goldring Centre for High Performance Sport

Toronto, Ontario, M5S2C9, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy, male, recreationally-active participants
  • Healthy will be defined as screened by the PAR-Q+ (The Physical Activity Readiness Questionnaire for everyone; Appendix. B). Active will be defined as being in the top 20% of age specific scores on iPAQ (the International Physical Activity Questionnaire; Appendix.C).
  • Participants are required not to engage in lower limb RT (resistance training) for at least 6 months prior to the study.
  • Participants will be 18-35 years old.
  • Participants are willing to abide by the compliance rules of this study

Exclusion criteria

  • Female
  • Inability to adhere to any of the compliance rules judged by principle investigator or medical doctor
  • Self-reported regular tobacco use
  • Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.)
  • The individual who has allergy for milk

Treatment and study plan

Active

Dietary Supplement

4g of essential amino acids

Placebo

Dietary Supplement

4g of maltdextrin

Primary outcomes

  1. Muscle protein synthesis

    Time frame: 4 hours

    Skeletal muscle fractional synthesis rate (%/h) will be determined by oral pulse method using ring-[D5]phenylalanine

Secondary outcomes

  1. exercise performance

    Time frame: 4 days

    Maximal strength (torque in n-M) of the knee extensors will be assessed by a maximal isometric voluntary contraction (MVC).

  2. Muscle soreness

    Time frame: 4 days

    Corresponding subjective ratings of muscle soreness will be collected from participants using a visual analogue scale (mm)

  3. Muscle damage

    Time frame: 4 days

    Muscle damage will be determined by histochemical analysis. muscle damage is defined as Z-band streaming.

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Collaborators

  • Ajinomoto Co., Inc.

Registry information

Official study title

Effect of Leucine-enriched Essential Amino Acid on Integrated Muscle Protein Synthesis and Muscle Recovery After Resistance Exercise

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Oct 24, 2017
Registry last updated
Apr 20, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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