Effect of Aloe Vera Gel as an Intra Canal Medicament

This research will overview the effect of aloe vera gel (AVG) as intra canal medicament in patients with asymptomatic periapical lesions. It will provide endodontists with scientific evidence regarding the beneficial use of AVG as an intracanal medicament owing to its superior antibacterial and analgesic properties as compared to routinely used commercial intra canal medicaments.

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Key information

Conditions

Periapical Diseases Jaw Diseases Mouth Diseases Pathological Conditions, Signs and Symptoms Periodontal Diseases Signs and Symptoms Stomatognathic Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Islamabad Dental Hospital

Islamabad, Federal, 44000, Pakistan

About this study

Objective: To evaluate the effect of aloe vera gel based on clinical signs and symptoms as an intracanal medicament in asymptomatic periapical lesions over a period of three weeks. Methodology: Fresh AVG will be prepared. It will be placed as intracanal medicament after cleaning and shaping in patients with asymptomatic periapical lesions in group A while in group B (control group) no intracanal medicament will be placed. Patients will be randomly divided into two groups by randomization in Statistical Package for Social Sciences software (SPSS v24.0). They will be recalled for one week and three week follow ups and in case of no clinical signs and symptoms endodontic procedure will be completed. Statistical analysis: Descriptive statistics will be used for reporting age. Frequencies and percentages will be calculated for categorical variables and intergroup comparison will be done by chi square test

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Both male and female patients presenting with asymptomatic periapical lesions in permanent teeth

Exclusion criteria

History of allergy to AVG

Comorbidities likely to impair healing
Pregnant women
History of previous endodontic treatment in the same tooth
Presence of pulp calcification
Internal or external root resorption

Treatment and study plan

Aloe vera gel

Biological

A fresh aloe vera (Aloe Barbadensis) leaf will be plucked from the plant. The leaf will be washed with normal saline, peeled with scalpel and the inner gel will be blended in a blender to convert it into a watery consistency. The solution will be stored in an autoclaved flask.

Primary outcomes

Presence or absence of signs and symptoms of the patient

Time frame: One week and 3 weeks
Patients in both the groups will be recalled after one week. They will be assessed clinically for either presence or absence of signs and symptoms.
- In cases of absence of clinical signs and symptoms, endodontic treatment will be completed.
- In cases where patient returns with presence of clinical signs and symptoms, dressing will be removed, and canals will be irrigated with sodium hypochlorite followed by saline. After drying the canals, in group A, AVG will be placed in the canals and tooth restored temporarily while in group B, cotton pellet will be placed in the canals and tooth restored temporarily. The patients will be recalled after two weeks.
- If a patient reports with acute symptomsin either of the groups, the protocols to manage acute infection will be followed.

Sponsors and collaborators

Lead sponsor

Islamabad Medical and Dental College

Other

Registry information

Official study title

Effect of Aloe Vera Gel as an Intra Canal Medicament in Patients With Asymptomatic Periapical Lesions.

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: Feb 6, 2024
Registry last updated: May 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed