"Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function"

This randomized clinical study evaluates two diuretic strategies for fluid overload in adult critically ill patients: furosemide monotherapy versus combined therapy with furosemide plus albumin. Albumin may enhance diuretic effectiveness by increasing intravascular oncotic pressure, improving renal perfusion, and facilitating drug delivery to the nephron.

The protocol includes standardized dosing, measurement of urine output at 2 hours, and analysis of serum and urine biochemical parameters. Bedside ultrasound will be used to assess markers of fluid overload, including evaluation of the inferior vena cava and venous congestion patterns. Hemodynamic variables, electrolyte changes, and estimated glomerular filtration rate will also be monitored.

The study aims to determine whether the co-administration of albumin provides a clinically meaningful improvement in diuretic response and renal function compared with furosemide monotherapy in critically ill patients with fluid overload.

Inclusion criteria

• Adults ≥18 years
• Critically ill patients admitted to the intensive care unit (ICU)
• Presence of oliguria defined as urine output <0.5 mL/kg/hour for at least 6 hours

Exclusion criteria

• Refusal to participate by the patient or legal representative
• Patients receiving palliative or end-of-life care
• Acute or chronic kidney failure requiring ongoing renal replacement therapy at enrollment
• Chronic dialysis dependency
• Participation in another interventional clinical trial
• Pregnant or lactating women