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Completed

NCT Number: NCT01668446

Effect of Adding Sildenafil to Protocol of Endometrial Preparation in Outcome of Frozen-thawed Embryo Transfer Cycles

The target of this study was an estimate the result of sildenafil on ultrasonographic endometrial thickness, endometrial pattern investigation estrogen level on the day of progesterone administration, Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles .

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Key information

Conditions

Endometrial Preparation Frozen Embryo Transfer

Age range

20 year–39 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Farzaneh Hojjat

Yazd, 8916878466, Iran

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women > 40 years old,
  • history of endocrine disease
  • Hysteroscopic surgery
  • cardiovascular, renal and liver disease
  • hypotension( blood pressure < 90/50)
  • history of stroke or myocardial infarction
  • use of alcohol or substance

Exclusion criteria

A total of 80 patients with antecedent of poor endometrial response and had frozen embryo included in this study all women must to be < 40 years old,

  • no history of endocrine disease,
  • no Hysteroscopic surgery, had a high quality embryos no cardiovascular,
  • renal and liver disease and
  • no hypotension (blood pressure < 90/50) or
  • history of stroke or myocardial infarction and
  • don't use of alcohol or substance Patients with these conditions enter this study and based on randomized tables are divided in two groups.

Treatment and study plan

Sildenafil

Drug

sildenafil tablets(50 mg) daily

estradiol valerat

Drug

Primary outcomes

  1. estimate the result of sildenafil on ultrasonographic endometrial thickness

    Time frame: between 2009-2011 (up to 2 years)

    Assays:

    Day 13 of menstrual cycle endometrial thickness estimated with Transvaginal ultrasonographic(arranged in a series every other day), evaluations were performed by a single investigator, If the endometrial thickness is more than 8mm progesterone injected 100 mg intramuscular and Estrogen, progesterone and lh measured in blood sample then after three days embryo transferred.

Secondary outcomes

  1. estimate the result of sildenafil on Implantation rate and chemical pregnancy rate in frozen embryo transfer cycles .

    Time frame: between 2009-2011 (up to 2 years)

    Implantation rate was higher in sildenafil Group but not significant chemical pregnancy rates were higher in sildenafil Group but not significant.

Sponsors and collaborators

Lead sponsor

farzaneh hojjat

Other

Collaborators

  • Razieh dehghani firouzabadi
  • Robab davar

Registry information

Acronym: sildenafil

Important dates

Study start
2009
Primary completion
2009
Study completion
2011
First posted
Aug 20, 2012
Registry last updated
Sep 13, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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