Skip to main content
OpenTrials
Completed

NCT Number: NCT05671172

Effect of Adding Hyaluronidase to Bupivacaine in Transversus Abdominis Plane Block for Cesarean Section

Since TAP block needs to affect several nerves in single tissue plane with a single prick, hyaluronidase is expected to aid greatly in the spread of the LA and help the block. However, there have not been adequate studies to establish the efficacy of adding hyaluronidase in lateral TAP after cesarean section. Hence, the present study was carried out to evaluate the efficacy of hyaluronidase in different concentrations added to bupivacaine in US-guided bilateral lateral TAP block.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Pain, Postoperative Neurologic Manifestations Pain Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Samar Rafik Amin

Banhā, Qalyubia Governorate, 13511, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • parturients who aged between 18-40 years old
  • with ASA physical status grade II and
  • scheduled for elective CS under spinal anesthesia

Exclusion criteria

  • patients with ASA grade III or IV,
  • refusal to participate,
  • emergency CS or complicated pregnancy,
  • those with bleeding disorders or on anticoagulants,
  • those with severe respiratory and cardiovascular diseases,
  • having any local infection at the injection site,
  • history of allergy to one of the used drugs,
  • obese patients (body mass index ≥ 30 kg/m2).

Treatment and study plan

Hyaluronidase

Drug

hyaluronidase will be applied as adjuvant to bupivacaine in transversus abdominis plane block to enhance the postoperative analgesic effect after CS

Bupivacaine Injection

Drug

20ml bupivacaine will be injected without additives in the transversus abdominis plane block on each side for postoperative analgesic after CS

Primary outcomes

  1. the duration of analgesia

    Time frame: 24 hours postoperative

    the interval between performing the block and the time of the first request for analgesia.

Secondary outcomes

  1. the postoperative pain severity

    Time frame: every 0,2,4,8,12, up to 24 hours postoperative

    pain was assessed by the visual analog scale (VAS) pain score (range, 0-10; 0, no pain; 10, worst pain)

  2. total morphine consumption

    Time frame: at 24 hours postoperatively

  3. patient satisfaction

    Time frame: at 24 hours postoperatively

    assessed on a four-point scale (1, excellent; 2, good; 3, fair; 4, poor)

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Effect of Adding Two Different Doses of Hyaluronidase to Bupivacaine in Ultrasound-Guided Transversus Abdominis Plane (TAP) Block for Post-cesarean Section Analgesia; A Randomized Controlled Double Blinded Study.

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 4, 2023
Registry last updated
Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.