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Completed

NCT Number: NCT01242033

Effect of Acute Red Raspberry Consumption on Post-prandial Oxidative Stress

Eight healthy adult subjects will be given a meal of one, two or four cups red raspberries, or two slices white bread with or without 200 mg vitamin C, after an overnight fast and consumption of a low polyphenol diet for two days. Blood samples will be taken at various time points over an eight hour period to measure oxidative stress and antioxidant levels in the blood. Each subject will attend 5 study visits with one week intervals and be given each meal in a random order. It is hypothesized that raspberry consumption at higher doses will greater protect against meal-induced oxidative stress compared to bread controls.

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Key information

Conditions

Oxidative Stress Antioxidants

Age range

20 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Nutrition and Risk Factor Modification Centre; St. Michael's Hospital

Toronto, Ontario, M5C 2T2, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy adults

Exclusion criteria

  • blood pressure greater than 120/80 mm Hg
  • body mass index greater than 24.9 kg/m^2
  • history of any chronic disease
  • currently taking medications
  • allergy to fruit

Treatment and study plan

red raspberries

Dietary Supplement

single serving of one, two or four cups red raspberries

bread controls

Dietary Supplement

two slices white bread alone or with 200 mg vitamin C supplement

Primary outcomes

  1. change in antioxidant capacity from baseline (-0.25 h)

    Time frame: -0.25, 0.25, 0.5, 1, 2, 4 hours post-intake

    plasma antioxidant capacity measured using the 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation assay and expressed in Trolox Equivalents (TE)

Secondary outcomes

  1. change in lipid peroxidation from baseline (-0.25 h)

    Time frame: -0.25, 0.25, 0.5, 1, 2, 4 hours post-intake

    serum thiobarbituric acid reactive substances (TBARS) measured as an indicator of the lipid peroxidation product malondialdehyde (MDA)

  2. change in thiols compared to baseline (-0.25 h)

    Time frame: -025, 0.25, 0.5, 1, 2, 4 hours post-intake

    plasma thiols quantified by 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) assay as an indicator of the level of protection against protein oxidation

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Collaborators

  • Unity Health Toronto

Registry information

Official study title

An Acute Intervention Study Investigating the Effect of Red Raspberry Consumption on Post-prandial Oxidative Stress

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Nov 16, 2010
Registry last updated
Dec 6, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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