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Completed

NCT Number: NCT06880614

Effect of Acute Protein Supplementation in Diabetic Patients

The goal of this trial is to test the effect of house cricket (Acheta domesticus) preload on glycemic response in diabetic patients. The main question[s] it aims to answer are: whether house cricket powder could lower blood glucose spike and stimulate higher insulin response. Participants will consume either house cricket powder, whey protein isolate or placebo which will be mixed with a chicken-flavored soup. Participants fingers will be pricked for up to 2 hours.

Researcher will compare house cricket powder with placebo to see if the glycemic response is better in house cricket supplemented group.

Researcher will compare house cricket powder with whey protein isolate to see if both supplement induce comparable glycemic response.

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Key information

Conditions

Diabetes Mellitus Type 2 Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Queen Elizabeth Hospital Kota Kinabalu

Kota Kinabalu, Sabah, 88200, Malaysia

About this study

Participants blood will be collected at 8 time points:

Baseline 20 minutes after pre load 15 minutes after Oral Glucose Tolerance Test (OGTT) 30 minutes after OGTT 45 minutes after OGTT 60 minutes after OGTT 90 minutes after OGTT 120 minutes after OGTT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Suffering from type 2 diabetes mellitus (HbA1c > 6.5%)
  • Consume metformin for at least 6 months

Exclusion criteria

  • Consume other type of anti-diabetic drugs
  • Presenting any food allergy
  • Recent surgery or infections that may affect oral glucose tolerance test
  • Consume other drugs that may affect oral glucose tolerance test
  • Not consuming any anti-diabetic drugs
  • Pre-diabetes (HbA1c 5.7 - 6.4%)

Treatment and study plan

Oral Glucose Tolerance test (75g 2-hour)

Diagnostic Test

The participants are required to drink a glucose solution containing 75 g of glucose dissolved in 250 mL of water

Whey

Dietary Supplement

Supplemented with whey protein isolate masked with a chicken-flavored soup

House cricket

Dietary Supplement

Supplemented with house cricket powder masked with chicken-flavored soup

Placebo

Dietary Supplement

Placebo consists of chicken-flavored soup without any supplement inside

Primary outcomes

  1. Blood glucose

    Time frame: 120 minutes

    Blood glucose concentration measured using glucometer. Participants fingers are pricked and using capillary tube, a drop of the blood is dripped in a test strip before inserted to a glucometer.

Secondary outcomes

  1. Blood insulin

    Time frame: 120 minutes

    Blood sample is collected through a finger prick. The blood will be centrifuged to obtain the serum. Insulin serum concentration is then measured by using ELISA kits. The blood sample are treated following the kit guideline, and the insulin concentration are measured by comparing the light absorbance against a prepared standard.

Sponsors and collaborators

Lead sponsor

University of Malaya

Other

Registry information

Official study title

Effect of House Cricket Preload on Glycemic Response in Type 2 Diabetes Patients

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 17, 2025
Registry last updated
Dec 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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