CHU Lille
Lille, 59000, France
Location status: Recruiting
Location contact
COTTENCIN Olivier
CONTACT
GAMELIN François-Xavier, PhD
CONTACT
Recruiting
NCT Number: NCT06081218
Effect of Acute Exercise on Cognitive Functions and Blood Markers of Brain Plasticity in Regular Chronic Cannabis Users
The endocannabinoid system (ECS) is a complex endogenous signaling system made up of transmembrane cannabinoid receptors (CB1 and CB2 receptors), their endogenous lipid-derived ligands (the endocannabinoids - eCBs), and enzymes for ligand biosynthesis and degradation. Interestingly, exercise increase plasma AEA, one of the most famous endocannabinoid. This increase could be involved in exercise-induced neurogenesis and other beneficial exercise adaptations. Chronic cannabis use is associated with alteration of ECS activity. The aim of the study is to compare ECS response to exercise between chronic cannabis users and non-users.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year–35 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Cannabis consumer group:
- Cannabis consumption > 100 times in lifetime, last exposure < 7 days, and recent exposure > 10 times in the month.
- Positive toxicological urine test for ∆-9-THC.
- Having a cannabis use disorder according to the CAST.
Healthy group:
- Negative urine toxicological test for cannabis.
- No regular cannabis use for more than 6 months once in a lifetime.
- No cannabis consumption in the 6 months preceding the study.
Exclusion criteria
For all subjects :
- Disorders of use of other substances (alcohol, cocaine, opioid, or synthetic drugs).
- Alcohol consumption greater than 30g per day (averaged over one week) and/or alcohol abuse the week preceding the visit.
- Under medical treatment.
- Presence of diagnosed neurological disorders.
- Diagnosis of a psychotic picture entering axis I, DSM-5.
- Chronic progressive disease or in remission.
- Body mass index > 30 kg/m2 (i.e. presence of obesity).
Treatment and study plan
activity test
OtherOver 2 weeks, participants have to do a maximal progressive exercise and a 30 min constant exercise at 50% of maximal aerobic power
Primary outcomes
-
Plasma endocannabinoids levels (pmol/ml)
Time frame: 2 weeks
Secondary outcomes
-
regulating hormone of endocannabinoids (plasma levels of cortisol, ng/ml)
Time frame: 2 weeks
-
Blood marker of neurogenesis and neuroplasticity (plasma levels and BDNF, pg/ml)
Time frame: 2 weeks
-
change in cerebral muscular, oxygenation (HHB), (HbO2), (Hbtot) (arbitrary unit)
Time frame: 2 weeks
-
Cognitive function (selective attention, stroop test)
Time frame: 2 weeks
The stroop test can be used to measure a person's selective attention capacity
-
Oxygen consumption (VO2) (ml/min/kg)
Time frame: 2 weeks
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
University Hospital, Lille
Other
Registry information
Acronym: CANNABEX
Important dates
- Study start
- 2024
- Primary completion
- 2029
- Study completion
- 2029
- First posted
- Oct 13, 2023
- Registry last updated
- May 15, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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