Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF

Inclusion criteria

• Married women aged 25-40;
• Repeated implantation failure for unknown reasons (experienced 2 or more embryo transfers of good-quality embryos without achieving clinical pregnancy);
• Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (≥3BB);
• Estrogen and progesterone replacement therapy (HRT), endometrial thickness ≥7mm on the day of endometrial transformation.

Exclusion criteria

Patients who met any of the following conditions were not included.

• Those who prepare for PGD;
• Recipients of egg donors;
• Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism);
• patients with implantation failure due to known embryonic factors;
• Uterine lesions that may affect implantation (including uterine malformation, >4cm intramural fibroids，submucosal fibroids, adenomyosis, uterine tuberculosis, intrauterine adhesions, etc.
• Repeated spontaneous abortion (2 or more fetal loss before 28 weeks of gestation);
• Patients with other endocrine diseases, such as thyroid disease, hyperprolactinemia, insulin resistance, diabetes, adrenal disease, etc., and poor control of hormone levels in the last 3 months;
• Clearly diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, etc.;
• Hydrosalpinx untreated;
• BMI less than 18 or higher than 25kg/m2;
• People with previous history of needle sickness;
• Those who have previously participated in this study or received acupuncture treatment in the past 3 months.
• Any situation that researchers consider inappropriate for participating in this study.