the First Affiliated Hospital of the Air Force Military Medical University
Xi'an, Shaanxi, China
Completed
NCT Number: NCT06521645
Effect of Acupoint Stimulation on Lactate During Cerebral Endovascular Intervention
It is advocated that neuroprotection should be increased before endovascular treatment and that the penumbra should be protected from reperfusion damage after recanalization. Monitoring lactate and pH levels in acute ischemic stroke patients who have had endovascular recanalization can be utilized to predict mortality and morbidity, especially in the first five hours after the procedure. This study aims to observe the effect of acupoint stimulation on lactate level during endovascular recanalization.
Completed
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Notify MeKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- age ≥18 years
- scheduled for cerebral endovascular intervention
Exclusion criteria
- American Society of Anesthesiologists status over level three
- history of cerebral vascular intervention
- history of severe neurological disease (stroke, neurological degenerative disease, psychiatric disease)
- severe hepatic or renal dysfunction
- severe glucose disorder or thyroid dysfunction
- contraindications to transcutaneous electrical stimulation (infection or injury of the skin area, implanted electrical devices)
Treatment and study plan
electroacupuncture
Otherelectrical stimulation is given through needles inserted into the skin
Sham Needle
Otherneedles are inserted shallowly into the skin
Primary outcomes
-
arterial level of lactate at 30 minutes after recanalization
Time frame: 30 minutes after recanalization
Secondary outcomes
-
arterial level of lactate immediately after recanalization
Time frame: about 1 minute after recanalization
-
pH value at 30 minutes after recanalization
Time frame: 30 minutes after recanalization
-
Concentration of HCO3- at 30 minutes after recanalization
Time frame: 30 minutes after recanalization
-
Concentration of base excess at 30 minutes after recanalization
Time frame: 30 minutes after recanalization
-
partial pressure of oxygen at 30 minutes after recanalization
Time frame: 30 minutes after recanalization
-
partial pressure of carbon dioxide at 30 minutes after recanalization
Time frame: 30 minutes after recanalization
-
pH value immediately after recanalization
Time frame: about 1 minute after recanalization
-
Concentration of HCO3- immediately after recanalization
Time frame: about 1 minute after recanalization
-
Concentration of base excess immediately after recanalization
Time frame: about 1 minute after recanalization
-
partial pressure of oxygen immediately after recanalization
Time frame: about 1 minute after recanalization
-
partial pressure of carbon dioxide immediately after recanalization
Time frame: about 1 minute after recanalization
-
Concentration of serum interleukin-6 at 30 minutes after recanalization
Time frame: 30 minutes after recanalization
-
Concentration of serum tumor necrosis factor α at 30 minutes after recanalization
Time frame: 30 minutes after recanalization
-
Concentration of serum brain-derived neurotrophic factor at 30 minutes after recanalization
Time frame: 30 minutes after recanalization
-
score of modified Rankin's scale at 24 hours after recanalization
Time frame: 24 hours after recanalization
the minimum and maximum values of modified Rankin's scale is 0 and 5, and higher scores mean a worse outcome.
-
incidence of stroke during hospitalization
Time frame: From end of surgery to discharge from hospital, at an average of 5 days
-
Incidence of death during hospitalization
Time frame: From end of surgery to discharge from hospital, at an average of 5 days
-
length of hospitalization
Time frame: From end of surgery to discharge from hospital, at an average of 5 days
Sponsors and collaborators
Lead sponsor
Air Force Military Medical University, China
Other
Registry information
Official study title
The Effect of Acupoint Stimulation on Level of Lactate in Patients Undergoing Cerebral Endovascular Intervention
Acronym: ASLA
Important dates
- Study start
- 2024
- Primary completion
- 2024
- Study completion
- 2024
- First posted
- Jul 26, 2024
- Registry last updated
- Jan 14, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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