Skip to main content
OpenTrials
Completed

NCT Number: NCT02020395

Effect of a Test Meal on Satiation Hormones in Obese and Normal Weight Adolescents

The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Endocrine System Diseases

Age range

11 year–16 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

University Hospital Basel, Division of Gastroenterology and Hepatology

Basel, 4031, Switzerland

About this study

The primary hypothesis is that obese adolescents have a disturbed balance of hormones associated with appetite regulation with less suppression of ghrelin and attenuated stimulation of GLP-1 secretion in response to meal intake compared to lean normal weight controls. A second aim of the study was to test which gastrointestinal peptides are most associated with insulin resistance.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • caucasian youth
  • pubertal Tanner stage x, y, or z

Exclusion criteria

  • fasting plasma glucose > 7.0 mmol/L
  • significant illness
  • taking medications

Treatment and study plan

test meal (500 kcal)

Dietary Supplement

whole wheat bread (68 g), butter(10 g), ham (25 g); chocolate cream (90 g); orange juice (200 mL)

Primary outcomes

  1. Comparison of gastrointestinal peptide secretion in normal weight and obese adolescents

    Time frame: 2 hours blood sampling

    Relation of GLP-1 release to insulin secretion in normal weight and obese adolescents

Secondary outcomes

  1. Association between gastrointestinal peptides and insulin release

    Time frame: 2 hours blood sampling

    Dynamics of gastrointestinal peptide secretion including Tmax and Cmax

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Collaborators

  • University Children's Hospital Basel

Registry information

Important dates

Study start
2009
Primary completion
2009
Study completion
2013
First posted
Dec 24, 2013
Registry last updated
Dec 24, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.