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OpenTrials
Completed

NCT Number: NCT00549614

Effect of 4 Weeks Treatment With Acipimox in Patients With Chronic Heart Failure

The primary objective of this study is to evaluate whether metabolic modulation improves left ventricular function, work capacity, insulin sensitivity and modifies substrate metabolism in chronic heart failure

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Key information

Conditions

Heart Failure Cardiovascular Diseases Heart Diseases

Age range

30 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Cardiology, Aarhus Universityhospital, Skejby

Aarhus N, 8200, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • EF<40 %
  • IHD
  • NYHA-class II-III.

Exclusion criteria

  • pregnancy
  • severe renal failure
  • new brady- or tachyArrhythmia
  • Severe stenotic valvular disease
  • myocardial infarction within last 6 weeks
  • insulin treated diabetes mellitus
  • peptic ulcer
  • pregnancy or lactating women
  • allergy towards tested medicine

Treatment and study plan

Acipimox

Drug

capsule, 250 mg, 4 times daily for 28 days

Placebo

Drug

capsule, 250 mg, 4 times daily for 28 days

Primary outcomes

  1. left ventricular ejection Fraction

    Time frame: 4 weeks

  2. exercise capacity

    Time frame: 4 weeks

  3. muscular metabolism

    Time frame: 4 weeks

Secondary outcomes

  1. regional left ventricular function

    Time frame: 4 weeks

  2. insulin resistance

    Time frame: 4 weeks

  3. full body metabolism

    Time frame: 4 weeks

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

Effect of 4 Weeks Treatment With Acipimox on Left Ventricular Function, Work Capacity, Insulin Sensitivity and Substrate Metabolism in Patients With Chronic Heart Failure

Acronym: ACME

Important dates

Study start
2007
Primary completion
2008
Study completion
2009
First posted
Oct 26, 2007
Registry last updated
Oct 7, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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