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Completed

NCT Number: NCT04111146

Effect of 25-OH-vitamin D3 on the Liver Transplant Recipients

The low vitamin D3 levels and malnutrition before liver transplantation showed an increase in the length of stay in ICU and hospital. Although several factors may influence the clinical outcomes of patients with liver transplantation, low vitamin D3 levels showed an independent risk factor. It is necessary to prospectively analyze the effect of vitamin D supplements on clinical outcomes in liver transplant recipients.

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Key information

Conditions

Liver Transplant Disorder

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hakjae Lee

Seoul, South Korea

About this study

Purpose: Vitamin D deficiency is common in patients of chronic liver disease and has been associated with infection and mortality. The aim of this study is to determine whether preoperative vitamin D levels affect clinical outcomes after liver transplantation.

Methods : This was a single-center retrospective study. Between June and November 2017, a total of 219 patients underwent liver transplantation. The primary outcome was the relationship between serum 25-OH-vitamin D3 level before liver transplantation and length of stay in the intensive care unit (ICU). Secondary outcomes included the duration of normalization of inflammatory marker, such as white blood cell count (WBC) & C-reactive protein (CRP) after liver transplantation, new infection rates, rejection rates, the length of hospital stay and mortality among vitamin D level.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The patients who admitted to intensive care unit (ICU) after liver transplantation were studied

Exclusion criteria

  • Patients who didn't have preoperative vitamin D level

Treatment and study plan

Primary outcomes

  1. Hospital stay after liver transplant

    Time frame: 6 months

    compared with each group

Secondary outcomes

  1. duration of normalization of CRP, WBC

    Time frame: 6 months

    compared with each group

  2. Length of ICU stay

    Time frame: 6 months

    compared with each group

  3. New infection rate

    Time frame: 6 months

    compared with each group

Sponsors and collaborators

Lead sponsor

Asan Medical Center

Other

Registry information

Official study title

The Clinical Effect of Preoperative Level of 25-OH-vitamin D3 on the Liver Transplant Recipients

Important dates

Study start
2017
Primary completion
2017
Study completion
2019
First posted
Oct 1, 2019
Registry last updated
Oct 1, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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