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Completed

NCT Number: NCT01543633

EEG Studies of Induction and Recovery From Propofol Induced General Anesthesia

The purpose of this study is to investigate how the commonly used anesthetic drug propofol works in the brain to produce loss of consciousness. While under general anesthesia your brain waves will be measured using electroencephalogram (EEG). On a separate day, the patient's brain will be imaged using magnetic resonance imaging (MRI).

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Key information

Conditions

Brain Activity Under Sedation

Age range

18 year–36 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy, non-smoking male and female volunteers, ages 18-36 with normal body weight.
  • American Society of Anesthesiologists (ASA) physical status I

Exclusion criteria

  • History of head trauma
  • Surgical aneurysm clips
  • Cardiac pacemaker
  • Prosthetic heart valve
  • Neurostimulator
  • Implanted pumps
  • Cochlear implants
  • Metal rods, plates
  • Screws
  • Intrauterine device
  • Hearing aid
  • Dentures (which might create NMR artifacts)
  • Metal injury to eyes

Treatment and study plan

Propofol

Drug

Propofol will be infused using a computer controlled delivery system running the program STANPUMP. Loss of consciousness will be defined as loss of response to auditory stimulus (button press).

Primary outcomes

  1. EEG Power in Alpha, Slow, and Delta Bands

    Time frame: 11 hours

    We used EEG measurements to study the dynamics of loss of consciousness, auditory processing, sensation, and memory under general anesthesia induced with propofol. The EEG data in each of the three specific aims will be analyzed using spectral methods, source localization, and event-related potentials. Through spectral analysis, EEG power (in decibels) in alpha, slow, and delta bands are measured.

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Collaborators

  • National Institutes of Health (NIH)

Registry information

Official study title

Electroencephalogram Studies of Induction and Recovery From Propofol Induced General Anesthesia

Important dates

Study start
2005
Primary completion
2020
Study completion
2020
First posted
Mar 5, 2012
Registry last updated
Jan 11, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.