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Completed

NCT Number: NCT03233282

EEG Monitoring for PERFormance Anticipation

Identify, characterize and then validate electrophysiological markers linking electrophysiological cerebral activity and performance in cognitive and physical fatigability in humans. To do this, noninvasive explorations of electroencephalography (EEG) and magnetoencephalography (MEG) will be carried out under two conditions of different experiments, the first one that induces a cognitive fatigability and the second one that induces physical fatigability.

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Key information

Conditions

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospices Civils de Lyon, HFME

Bron, 69500, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

MGPFco group:

  • Adult subjects, male or female, right-handed or left-handed, from 18 years up to 70 years;
  • Having duly completed the entire confidential medical questionnaire;
  • Written consent of free, informed and express participation;
  • No hearing problems;
  • Having normal or corrected vision;
  • Affiliation to a Social Security scheme.

Inclusion criteria

MGPFph group:

  • Adult subjects, male or female, right-handed or left-handed, from 18 years up to 35 years;
  • Practicing at least five hours of sports per week;
  • Presenting a certificate of no contraindication to an exercise test, intense sports practice or an energy sport in competition of the current year;
  • Having duly completed the entire confidential medical questionnaire;
  • Without cardiovascular or motor disability;
  • Without tumoral, inflammatory, cardiac, pulmonary, renal, digestive (malabsorption syndrome) or liver disease;
  • Written consent of free, informed and express participation;
  • Affiliation to a Social Security scheme.

Exclusion criteria

  • Pregnant women, nursing mothers or those of childbearing age without contraception
  • Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of liberty or of liberty
  • Persons protected by the law
  • Persons who have performed a maximum stress test within 15 days of the date of inclusion,
  • In the course of drug treatments against indicated for the protocol (treatment for neurological diseases, psychiatric ...).
  • Metal implants incompatible with MRI (for the subjects concerned, see appendices)
  • Metallic implants incompatible with the MEG (for the subjects concerned, see appendices)

Treatment and study plan

Electroencephalography (EEG) multi-sensor

Other

Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG), which is a non-invasive method.

Magnetoencephalography (MEG)

Other

Electrophysiological measurements of brain activity will be performed by magnetoencephalography (MEG) which is a non-invasive method.

Behavioral Measures

Other

The evaluation of cognitive performance will be carried out by means of behavioral measures, push-button type, handling of a mouse or a joystick.

Reaction time measurement

Other

The assessment of cognitive performance will be carried out using standard behavioral measures, such as reaction time measurement.

Assessment of physical performance

Other

The assessment of physical performance will be based both on bioenergetic measurements and on quantitative data collected in continuous and relative to the effort (eg instantaneous pedaling speed).

Electrooculogram (EOG)

Other

In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.

Electromyogram (EMG)

Other

In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.

Electrocardiogram with 3 leads

Other

In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.

Electrodermogram (EDG)

Other

In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.

Consumption of O2 (VO2)

Other

In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.

Production of CO2 (VCO2)

Other

In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.

Primary outcomes

  1. Identify electrophysiological markers in humans depending on whether the experimental conditions induce cognitive fatigability.

    Time frame: 7 hours

    The evaluation of cognitive performance will be carried out by means of conventional behavioral measures, of the press-button type, handling of a mouse or of a joystick and measurement of reaction time.

  2. Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with EEG.

    Time frame: 7 hours

    Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG).

  3. Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with MEG.

    Time frame: 7 hours

    Electrophysiological measurements of cerebral activity will be carried out by magnetoencephalography (MEG)

Secondary outcomes

  1. Refine (locate at the level of the cortex), the origin of these physiological markers

    Time frame: 7 hours

    Several types of recordings, passive and non-invasive, will be realized:

    • Electrooculogram (EOG);
    • electromyography (EMG);
    • electrocardiogram (ECG); Systematically in "physical" experiments and for some "cognitive" experiments.
  2. Distinguish between different time scales of performance

    Time frame: 7 hours

    Several types of recordings, passive and non-invasive, will be realized:

    • electrodermogram (EDG);
    • the consumption of O2 (VO2);
    • production of CO2 (VCO2). Only and systematically, in "physical" experiments.

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Electrophysiological and Bioenergetic Study of Variations in Cognitive and Physical Performance in Healthy Humans: EEG Monitoring for PERFormance Anticipation

Acronym: MEEGAPERF

Important dates

Study start
2013
Primary completion
2018
Study completion
2018
First posted
Jul 28, 2017
Registry last updated
Oct 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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