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OpenTrials
Completed

NCT Number: NCT02543554

ED Lung Protective Ventilation to Reduce Complications

Early mechanical ventilation, if delivered with injurious settings, can lead to pulmonary complications, such as acute respiratory distress syndrome (ARDS). Mechanical ventilation in the emergency department (ED) has been studied infrequently when compared to the intensive care unit; however, data suggests that ED-based mechanical ventilation has significant room for improvement and may also be a causative factor in ARDS incidence.

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Key information

Conditions

Mechanical Ventilation ARDS Ventilator-associated Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Washinton University School of Medicine in St. Louis

St Louis, Missouri, 63110, United States

About this study

This is a before-after study examining the impact of implementing lung protective ventilation in the emergency department.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • mechanically ventilated via an endotracheal tube in the ED

Exclusion criteria

  • death in the ED,
  • death or discontinuation of ventilation within 24 hours,
  • chronic mechanical ventilation,
  • ARDS while in the ED
  • transfer to another hospital.

Treatment and study plan

Lung Protective Ventilation

Procedure

Lung protective ventilation strategy, which aims to deliver safe tidal volumes, appropriate PEEP, limit plateau pressure, and limit hyperoxia.

Primary outcomes

  1. Number of Patients That Experience Pulmonary Complications After Admission From the Emergency Department

    Time frame: 7 days

Secondary outcomes

  1. Number of Patients That Die During the Hospitalization

    Time frame: Patients will be followed for the duration of hospital stay

Sponsors and collaborators

Lead sponsor

Washington University School of Medicine

Other

Registry information

Official study title

The Effect of Lung Protective Ventilation Initiated in the Emergency Department on the Incidence of Pulmonary Complications and Clinical Outcomes

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Sep 7, 2015
Registry last updated
Dec 3, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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