Ectopic Pregnancy Biomarkers

In an attempt to simplify the diagnosis of ectopic pregnancy, the researchers will investigate the presence of specific molecular markers of ectopic pregnancy. The quantification of these (and other proteins) will be performed using the Ciphergen Protein Chip system where serum is sampled with a high-throughput system. The patterns of these peaks will be compared for those with a diagnosis of ectopic pregnancy and normal pregnancy. Later goals of the research will be to identify the actual proteins that correspond to the peaks which discriminate between the two clinical entitles. The goal is to identify a unique protein pattern or protein peak to distinguish a normal intrauterine pregnancy from that of an ectopic implanted gestation.

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Key information

Conditions

Ectopic Pregnancy Female Urogenital Diseases and Pregnancy Complications Pregnancy Complications Pregnancy, Ectopic Urogenital Diseases

Sex eligibility

Female

Study type

Observational

Primary location

University of Southern California Women's and Children's Hospital, Los Angeles, California, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Reproductive-aged women
Currently pregnant based on serum human chorionic gonadotropin level
Present for care for pregnancy due to vaginal bleeding and/or pelvic cramping
Final diagnosis of one of the following:

Live intrauterine pregnancy through 14 weeks, diagnosed by ultrasound demonstrating fetal heart motion
Diagnosed ectopic pregnancy
Ultrasound confirmation of a nonviable gestation (less 14 weeks) such as an anembryonic gestation or a fetal demise

Exclusion criteria

None

Sponsors and collaborators

Lead sponsor

University of Pennsylvania

Other

Collaborators

Bill and Melinda Gates Foundation
National Institutes of Health (NIH)

Registry information

Official study title

Serum Bank for Assessment of Markers of Ectopic Pregnancy

Important dates

Study start: 2000
Primary completion: 2013
Study completion: 2013
First posted: Sep 19, 2005
Registry last updated: Aug 16, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed