Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly

This study investigates fat distribution in people with acromegaly. The investigator is also investigating the change of fat distribution before and after treatment of acromegaly. The investigator will compare the results of people with acromegaly to the results of healthy volunteers.

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Key information

Conditions

Acromegaly Bone Diseases Bone Diseases, Endocrine Brain Diseases Central Nervous System Diseases Endocrine System Diseases Hyperpituitarism Hypothalamic Diseases Musculoskeletal Diseases Nervous System Diseases Pituitary Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Ages 18 - 75 yr (both groups)
Study subjects with active acromegaly
Healthy controls

Exclusion criteria

Serum creatinine or alanine aminotransferase (ALT) > 2 times the upper limit of normal, metastatic cancer.
Controls will be receiving no medications and have no chronic diseases, including cancer, hypertension or diabetes mellitus.
Contraindications to MRI imaging (both groups) like those with certain metal implants, surgical clips or pacemakers.
Pregnant women

Treatment and study plan

Primary outcomes

Change in Liver Fat

Time frame: Baseline and 3-month follow-up visit

Change in intrahepatic fat after biochemical control of acromegaly
Change in Thigh Muscle Cross-sectional Area

Time frame: Baseline and 3-month follow-up visit

Change in thigh muscle cross-sectional area after biochemical control of acromegaly

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Collaborators

Ipsen

Registry information

Important dates

Study start: 2013
Primary completion: 2016
Study completion: 2016
First posted: Mar 28, 2013
Registry last updated: Jun 20, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed