Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07719179

Eco-guided Neuromodulation of the Femoral Nerve on the Performance of Amateur Athletes.

This randomized crossover study aims to evaluate whether different percutaneous electrical nerve stimulation (PENS) protocols produce changes in neuromuscular performance in healthy adults. PENS involves the ultrasound-guided application of an electrical current through a needle to modulate motor neuron excitability. Each participant will undergo five intervention sessions: (1) a long-term potentiation (LTP)-based protocol with impulse trains, (2) a 10 Hz protocol with 10 s stimulation and 10 s rest repeated ten times, (3) a 5-55 protocol with 100 Hz stimulation for 5 s followed by 55 s rest repeated five times, (4) a high-intensity burst (HIB) protocol applied at a high current intensity close to 1000 mA and repeated three times, and (5) a placebo condition. All interventions will be applied bilaterally by an experienced physiotherapist under ultrasound guidance, with a two-week washout between sessions. The objective of this trial is to assess whether these stimulation patterns produce measurable changes in squat execution velocity, jump performance, and quadriceps strength. The findings may help identify the most effective stimulation strategy for enhancing neuromuscular performance.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universitat Internacional de Catalunya

Sant Cugat del Vallès, Barcelona, 08195, Spain

Location status: Recruiting

Location contact

Jacobo Rodríguez Sanz, PhD

CONTACT

[email protected]

+34 636 136 789

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Athletes aged between 18 and 30 years.
  • Familiarized with performing barbell back squats using an Olympic bar.
  • Engaged in regular training at least three times per week during the last six months.
  • Able to perform squat and jump tests safely.
  • Provided written informed consent to participate in the study.

Exclusion criteria

  • Sports injury within the last two months or current inability to perform physical activity.
  • Inability to understand or follow the instructions provided by the therapist.
  • Participation in another research study during the same period.
  • Belonephobia (fear of needles).
  • Ongoing medical or pharmacological treatment that could interfere with neuromuscular performance (e.g., anticonvulsants, antidepressants, or similar medications).

Treatment and study plan

Theta Burst Protocol

Device

The intervention consists of the bilateral, ultrasound-guided insertion of a needle for percutaneous electrical nerve stimulation (PENS), following a theta-burst pattern designed to produce long-term potentiation-like effects. An asymmetric biphasic compensated current with a rectangular positive phase and a triangular negative phase is applied at a frequency of 100 Hz for 5 seconds, followed by 55 seconds of rest, repeated five times. The pulse width is 240 µs, and the intensity is maintained above the motor threshold and below the pain threshold.

Other names: Impulse Train Protocol

10-10-10 Protocol

Device

Percutaneous electrical nerve stimulation (PENS) applied under ultrasound guidance at 10 Hz, consisting of 10 seconds of stimulation followed by 10 seconds of rest, repeated ten times. The current intensity is adjusted to produce visible muscle contraction without pain.

5-55 Protocol

Device

Percutaneous electrical nerve stimulation (PENS) applied under ultrasound guidance at 100 Hz for 5 seconds, followed by 55 seconds of rest, repeated five times. The current intensity is adjusted to elicit a mild tingling sensation while remaining below the pain threshold.

PLACEBO

Device

A sham PENS procedure involving ultrasound-guided needle insertion at the same anatomical site without electrical stimulation. The device is manipulated to simulate treatment, but no current is delivered. Participants are informed they might not feel any sensation during the session.

High-Intensity Burst (HIB) Protocol

Device

Percutaneous electrical nerve stimulation (PENS) applied under ultrasound guidance using high-intensity bursts delivered bilaterally at a current intensity close to 1000 mA, repeated three times. The stimulation intensity is individually adjusted to approach but not exceed the participant's tolerance threshold.

Other names: High Intensity Burst, HIB

Primary outcomes

  1. Changes in squat execution velocity (m/s) measured with a linear encoder

    Time frame: pre-intervention, immediately after the intervention

Secondary outcomes

  1. Changes in vertical jump performance (jump height) measured with the MyJump2 app.

    Time frame: pre-intervention, immediately after the intervention

  2. Changes in quadriceps strength measured in newtons using a force gauge

    Time frame: pre-intervention, immediately after the intervention

  3. Changes in muscle activation in microvolts (μV) measured via surface electromyography

    Time frame: pre-intervention, immediately after the intervention

Study contacts

Contact information is provided by the study sponsor or research team.

Jacobo Rodríguez Sanz, PhD

CONTACT

[email protected]

+34 636-136-789

Sponsors and collaborators

Lead sponsor

Universitat Internacional de Catalunya

Other

Registry information

Official study title

Effectiveness of Eco-guided Neuromodulation of the Femoral Nerve on the Performance of Amateur Athletes. Randomized Controlled Crossover Clinical Trial

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 22, 2026
Registry last updated
Jul 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.