Eccentric Manual Resistance Training in Patients With Ischemic CMP

BACKGROUND: Eccentric resistance training demonstrated positive effects in ischemic cardiomyopathy patients in several studies. These studies were mainly set on device-based training interventions comparing eccentric-orientated and concentric-orientated training. Eccentric-orientated training induced comparable positive effects on cardiac and functional levels and even better effects on muscle strength improvement.

RESEARCH AIMS: The aim of the study is to determine if eccentric-orientated body weight and manual resistance training in ischemic cardiomyopathy patients will allow a more significant improvement in maximum voluntary contraction force of the knee extensors compared to concentric training.

In contrast to previous studies, these interventions will be set without use of training devices.

In addition, changes in the muscle cross section of the quadriceps muscle will be calculated by skeletal muscle ultrasound. Functional changes and quality of life will be assessed using one minute sit to stand test, six minutes walking test and Kansas City Cardiomyopathy Questionnaire. Cardiac outcome parameters will be assessed by using body composition and hemodynamic parameters as well as echocardiography, laboratory values and specific biomarkers for sarcopenia / cachexia.

METHODS: The investigators propose to run a monocentric, prospective, double arm, open, randomized controlled trial. Eccentric-orientated training will be delivered to 30 ischemic cardiomyopathy patients.

These patients will be randomized into two groups at the beginning, followed by a 6-weeks observation phase (without intervention for internal quality control of the measurement parameters). The intervention-phase will consist of six weeks of three times weekly either eccentric or concentric-oriented training.

Outcome measurements will take place after randomization, after 6 weeks of observation as well as after the intervention phase

Inclusion criteria

• Male / female, 45-85a
• Ischemic cardiomyopathy with mildly reduced ejection fraction (40 -50%)
• Coronary heart disease

Exclusion criteria

• Acute coronary syndrome, myocarditis or pericarditis in the last 3 months
• Cardiac decompensation in the last 3 months
• Severe symptomatic heart failure NYHA IV (New York Heart Association)
• Device - carrier (ICD= Intracardial Defibrillator, CRT= Cardiac Resynchronization Therapy, PM=Pacemaker)
• Hemodynamically significant valvular disease
• Symptomatic cardiac arrhythmia
• Intractable, uncontrolled hypertension (repetitive blood pressure > 150/100)
• Severe comorbidities, which lead to study exclusion by the investigator
• Pregnancy / nursing