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Completed

NCT Number: NCT07581067

Eccentric Exercise, Muscle Damage, and Oxygen Uptake Across Menstrual Cycle Phases

The existing literature examining the effect of female sex hormones across the phases of the menstrual cycle on muscle microdamage and oxygen uptake is limited. The protective role of estrogens against muscle microdamage is supported by findings from some studies; however, it is questioned by others. The aim of the present study was to investigate the effect of eccentric exercise on biomarkers of muscle microdamage and on oxygen uptake during two phases of the menstrual cycle in healthy premenopausal women.

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Key information

Conditions

Menstrual Cycle Exercise Performance Impairment

Age range

18 year–28 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Department of Physical Educaiton and Sport Science

Dafni, Attica, 17234, Greece

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • No known medical history
  • Not receiving any medication or dietary supplementation.
  • Stable menstrual cycle

Exclusion criteria

  • Pathological conditions the last month before enrolment in the study
  • Low limb injury the past 4 months
  • Unstable menstrual cycle

Treatment and study plan

Isokinetic eccentric exercise using knee extensors of the right lower limb

Other

Isokinetic eccentric exercise consisted of 10 min at 40% of maximal voluntary contractions, followed by 2 min maximal intensity muscle effort

Isokinetic eccentric exercise using knee extensors of the left lower limb

Other

Isokinetic eccentric exercise consisted of 10 min at 40% of maximal voluntary contractions, followed by 2 min maximal intensity muscle effort

Primary outcomes

  1. Maximal isometric torque

    Time frame: From enrollment to the end of the intervention at 2 weeks

    maximal performance during 5 sec isometric knee extensors contraction, assessed pre and 48 h post eccentric exercise

  2. Delayed onset muscle soreness

    Time frame: From enrollment to the end of intervention at 2 weeks

    Palpation of the muscle belly, performed pre and 48h post eccentric exercise

  3. Oxygen consumption

    Time frame: From enrollment to the end of the intervention at 2 weeks

    During the isokinetic eccentric exercise, participants were attached to a gas analyser for continuously measuring oxygen consumption.

  4. Duration of the isokinetic exercise

    Time frame: From enrollment to the end of intervention at 2 weeks

    The total duration of exercise performed on the isokinetic dynamometer was recorded

Sponsors and collaborators

Lead sponsor

National and Kapodistrian University of Athens

Other

Registry information

Official study title

The Effect of Eccentric Exercise on Biomarkers of Exercise Induced Muscle Damage and Oxygen Uptake: Differences Between Phases of the Menstrual Cycle

Acronym: EEMDO-MC

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
May 12, 2026
Registry last updated
May 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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