Eating Behaviour and Gustatory Sensitivity Before and After Liver Transplant in Cirrhotic Patients

Today, we know that olfactogustatory alterations occur in cirrhotic patients before the liver transplant but no study has been conducted to show eventual disturbances after the transplantation able to explain modifications in eating behaviour. In parallel, the metabolic status, itself dependent on liver metabolism, influences food preferences and is modified after the transplantation as the liver recovers its ability to store glycogen, but is not able to inform the brain as the afferent nerve impulses have been suppressed. The innovative aspect of this project is to provide information on the importance of the liver in the regulation of energy homeostasis.

The results of this study will improve our understanding of eating behaviour and olfactogustatory sensitivity and allow us to orient liver transplant patients towards appropriate diets.

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Key information

Conditions

Eating Behaviour Behavior Behavior, Animal Feeding Behavior Liver Transplant

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre Hospitalier Universitaire

Dijon, 21079, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

persons who have provided written informed consent
persons aged between 18 and 70 years
persons waiting for a liver transplantation (group LT)
persons with stable liver damage
persons waiting for a kidney transplantation (KT)
healthy subjects (control group) no known disease

Exclusion criteria

persons without national health insurance cover
persons with chronic infection,
persons with acute infection,
persons with progressive cancer,
persons with an antibiotic treatment,
persons who drink alcohol,
pregnant or breast-feeding women,
persons with an aversion to the foods proposed in the study,
persons taking treatments known to interfere with gustatory and olfactory performance,
adults under guardianship

Treatment and study plan

Respiratory quotient

Other

Olfactory liking

Other

Primary outcomes

Change in respiratory quotient (RQ) by indirect calorimetry compared with baseline values

Time frame: At month 0, month 3, month 9 and month 15
Change in olfactory liking compared with baseline values by questionnaire

Time frame: At month 0, month 3, month 9 and month 15

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire Dijon

Other

Registry information

Acronym: GREFFE

Important dates

Study start: 2015
Primary completion: 2019
Study completion: 2019
First posted: Aug 9, 2016
Registry last updated: Feb 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed