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NCT Number: NCT07718373

Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery

Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.

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Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

·adults admitted to the ICU after CPB-assisted cardiac surgery

Exclusion criteria

  • congenital heart disease,
  • surgery requiring deep hypothermic circulatory arrest,
  • a preoperative baseline estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m²,
  • AKI already present prior to ICU admission

Treatment and study plan

L-arginine

Drug

Initiation of L-arginine within 3 postoperative days

Primary outcomes

  1. Acute kidney injury

    Time frame: within 7 postoperative days

    defined by KDIGO criteria

Secondary outcomes

  1. Acute kidney injury stage

    Time frame: within 7 postoperative days

    defined by KDIGO criteria

  2. in-hospital mortality.

    Time frame: up to 48 weeks

    in-hospital mortality.

Study contacts

Contact information is provided by the study sponsor or research team.

Zefei Zhang

CONTACT

[email protected]

18811797795

Sponsors and collaborators

Lead sponsor

Xijing Hospital

Other

Registry information

Official study title

Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery: a Target Trial Emulation

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jul 22, 2026
Registry last updated
Jul 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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