Early Markers of Radiation-Induced Cardiac Injury in Hodgkin Lymphoma Treated With Radiation Therapy

The purpose of this study is to evaluate if radiation and chemotherapy treatment cause cardiac abnormalities among survivors of Hodgkin's lymphoma.

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Key information

Conditions

Hodgkin's Lymphoma Hemic and Lymphatic Diseases Hodgkin Disease Immune System Diseases Immunoproliferative Disorders Lymphatic Diseases Lymphoma Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Florida Health Proton Therapy Institute

Jacksonville, Florida, 32206, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Completed radiation and chemotherapy treatment for Hodgkin lymphoma involving the mediastinum.
Patient must be ≥ 18 years at time of consent.

Exclusion criteria

Pregnant women at time of Cardiac MRI
Contraindications to Cardiac MRI (contrast allergy, metal implants, medical devices)
Glomerular filtration rate (GFR) < 30, unless approved by Radiologist (UF Health Jacksonville Radiology Policy: Administration of Gadolinium-Based Contrast Agents).

Treatment and study plan

Cardiac Magnetic Resonance Imaging

Procedure

A cardiac MRI will be performed.

Echocardiogram

Procedure

An echocardiogram will be performed for the following information: M-mode, two-dimensional, Doppler blood flow measurements, and longitudinal strain and strain rate imaging

Primary outcomes

Cardiac Abnormalities As Measured By Cardiac MRI

Time frame: Day 1
Cardiac Abnormalities As Measured By Echocardiogram

Time frame: Day 1

Sponsors and collaborators

Lead sponsor

University of Florida

Other

Registry information

Official study title

UFPTI 1431 - HL02: Investigating Early Markers of Radiation-Induced Cardiac Injury in Hodgkin Lymphoma Survivors Treated With Either Photon or Proton Radiation

Important dates

Study start: 2015
Primary completion: 2021
Study completion: 2021
First posted: Apr 1, 2015
Registry last updated: Jun 10, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed