Skip to main content
OpenTrials
Completed

NCT Number: NCT05420610

Early Goal-Directed Therapy Utilizing Transpulmonary Thermodilution and Severe Burn Injury

This study aimed to optimize fluid resuscitation with transpulmonary thermodilution (TPTD)-guided protocol and to lower the mortality rate of the severely burned.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Burns Wounds and Injuries

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, 83301, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (age > 18 years).
  • Major burn (as total burned surface area (TBSA) > 20% with at least second degree burn depth).
  • Admitted to the intensive care unit (ICU) of the Burn Center.

Exclusion criteria

  • Patients younger than 18 years old.
  • Patients with severe cardiopulmonary diseases, or associated with other major trauma.
  • Patient with incomplete data.

Treatment and study plan

Control group: Patients being admitted when The advancement of transpulmonary thermodilution(TPTD) device was unavailable.

Other

The control group included patients being admitted when TPTD device was unavailable; and relatively stable patients without the need for TPTD. The adequacy of fluid resuscitation in the control group was monitored by traditional monitoring parameters including vital signs and hourly urine output.

Study group: TPTD device was implemented for monitoring.

Other

TPTD device was implemented for monitoring; the inclusion criteria included patients suffering from 2nd degree burn greater than 40% TBSA; a combined 2nd to 3rd degree burn greater than 30% TBSA; or patients with inhalation injury despite the burned surface area.

Primary outcomes

  1. Patient mortality

    Time frame: Up to 6 months

    The primary outcome was patient mortality after major burn.

Sponsors and collaborators

Lead sponsor

Chang Gung Memorial Hospital

Other

Registry information

Official study title

Early Goal-Directed Therapy Utilizing Transpulmonary Thermodilution for Treating Adult Patients With Severe Burn Injury

Important dates

Study start
2021
Primary completion
2021
Study completion
2022
First posted
Jun 15, 2022
Registry last updated
Jun 15, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.