Early Diagnosis of Asthma in Young Children

The overall aim of the study is an early asthma diagnosis in young children by the use of non-invasive biomarkers of airway inflammation /oxidative stress in exhaled air, and early lung function measurements

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Key information

Conditions

Asthma Bronchial Diseases Disease Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

2 year–4 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University Medical Centre

Maastricht, Limburg, 5800, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Children aged 2-3 years, with recurrent respiratory symptoms suggestive of asthma
Children aged 2-3 years, with no or minor respiratory symptoms

Exclusion criteria

Mental retardation
Cardiac anomalies
Congenital malformations
Other diseases of the lungs/airways
Chronic systemic inflammatory diseases like M. Crohn
The inability to perform lung function measurements and/or exhaled air collection

Treatment and study plan

beclomethasondipropionate

Drug

2 x 100 ug dd for two months, via aerochamber

Other names: Qvar Extra Fijn

Primary outcomes

- definite asthma diagnosis - biomarkers in exhaled breath

Time frame: 6 years of age

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Collaborators

Stichting Astma Bestrijding, The Netherlands
The Netherlands Asthma Foundation

Registry information

Important dates

Study start: 2007
Primary completion: 2011
Study completion: 2012
First posted: Jan 17, 2007
Registry last updated: Jun 18, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed