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Completed

NCT Number: NCT00684281

Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment

The aim of this project is to follow cohort of patients with aMCI in order to establish whether there are distinct subgroups in terms of evolution or aetiology, with distinct memory profiles and profiles of mesiotemporal atrophy and metabolic change

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Key information

Conditions

Alzheimer's Disease Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Age range

50 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hopital de la Timone- Service de neurologie et de neuropsychologie

Marseille, 13005, France

About this study

The syndrome of "amnestic Mild Cognitive Impairment" (aMCI) has been introduced for patients with intact activities of daily living, with a memory complaint and objective memory decline on neuropathological assessment, without significative change in other domains of cognition. Follow-up in these patients shows that the memory impairment may remain stable or improve, while it worsens or extends to other cognitive domains in others, indicating prodromal AD.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients beforehand include in the PHRC 2001 study (These patients presented to the inclusion in the PHRC 2001 a qualified board of amnestic Mild Cognitive Impairment [aMCI] or light cognitive confusion of type amnestic)
  • The patient must be affiliated to an insurance scheme disease to participate in this study

Exclusion criteria

  • For the magnetic resonance imaging: usual contraindications for an examination by MRI: claustrophobia, metal foreign bodies, pacemakers, etc.
  • Incapacitated to realize the neuropsychological evaluation because of medical intercurrentes disorders
  • Appointment of a guardian

Treatment and study plan

Neurological and neuropsychological consultation, MRI

Other

Neurological and neuropsychological consultation, MRI for the month 0, 18 and 36

Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA

Other

Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA, months 0/18/36

Primary outcomes

  1. Pursue the longitudinal study of a troop of subjects presenting an amnestic MCI in 36 months after the initial diagnosis

    Time frame: 36 months

  2. Characterize the clinical evolution of these subjects: escalation with appearance of an insanity (of type Alzheimer's disease or of another type: degenerations fronto-temporal, insanity with body of Lewy), stabilization even improvement.

    Time frame: 36 months

  3. Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict an escalation

    Time frame: 36 months

  4. Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict a stabilization or an improvement.

    Time frame: 36 months

  5. Improve the state of the knowledge on the origin of the confusions mnésiques isolated at the persons of fifty and more years old.

    Time frame: 36 months

Secondary outcomes

  1. Establish diagnostic criteria which allow to improve the sensibility and the specificity of the premature diagnosis of MY.

    Time frame: 36 months

  2. Determine if the ultra-premature diagnosis of MY at a stage where the hurts are still confined in the structures under - hippocampiques is possible.

    Time frame: 36 months

  3. Determine the specific character or not of the infringement of the memory of visual recognition in the novice Alzheimer's disease.

    Time frame: 36 months

  4. Determine the specific character or not the atrophy and the metabolic modifications of regions under - hippocampiques in the novice Alzheimer's disease.

    Time frame: 36 months

  5. Inform the existence of process of functional compensation in the population of aMCI, notably to those who show themselves stable or improve.

    Time frame: 36 months

Sponsors and collaborators

Lead sponsor

Assistance Publique Hopitaux De Marseille

Other

Registry information

Important dates

Study start
2008
Primary completion
2011
Study completion
2011
First posted
May 26, 2008
Registry last updated
Aug 28, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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