Early Diagnosis of Acute Renal Failure by Urine Trehalase Levels.

We think that in surgical patients requiring hypotensive anesthesia, acute kidney injury, which may occur due to intraoperative renal hypoperfusion, can be diagnosed early by evaluating the urine trehalase value using the ELISA method, and thus, early diagnosed acute renal failure can be treated quickly and patients can be protected from subsequent complications in the postoperative period.

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Key information

Conditions

Trehalase Levels Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Istinye Üniversity

Istanbul, Merkez Mahallesi, 34250, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Being over the age of 18 and under the age of 65
Having signed the BGOF form to be included in the study,
Being in ASA 1 or ASA 2 classification
Not having kidney failure or kidney disease
No history of single kidney or renal transplantation
Not using nephrotoxic drugs or agents before surgery
Renal function tests taken preoperatively should be within normal ranges.
No urinary tract infection or urinary problems (such as polyuria, oliguria or anuria)

Exclusion criteria

Those under the age of 18 or over the age of 65
Those who do not want to participate in the study
ASA 3 and above
Having previously received treatment for kidney disease - including kidney stones -
Having been previously diagnosed with acute or chronic renal failure
Having a single kidney or a history of renal transplantation
Using nephrotoxic drugs or agents (such as contrast material) before surgery
Kidney function tests taken preoperatively are not within normal ranges
Having a urinary tract infection or urinary problem (such as polyuria, oliguria or anuria)
Having a history of kidney stones, acute renal failure or chronic renal failure
Those with active infection or disease before surgery
They were determined as patients for whom consent was not obtained for the study.

Treatment and study plan

trehalase levels

Diagnostic Test

Primary outcomes

trehalase levels

Time frame: 1 month

urine trehalase levels

Study contacts

Contact information is provided by the study sponsor or research team.

ilke dolgun

CONTACT

[email protected]

+905555485632

Sponsors and collaborators

Lead sponsor

Istinye University

Other

Registry information

Official study title

Early Diagnosis of Acute Renal Failure, Which May Occur in Patients After Surgeries Requiring Hypotensive Anesthesia, by Urine Trehalase Levels.

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2024
First posted: Jul 17, 2024
Registry last updated: Jul 17, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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