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OpenTrials
Completed

NCT Number: NCT00673283

Early Detection of Lung Cancer Via Bi-plane Correlation Chest Imaging

This project proposes a new method, Bi-plane Correlation Imaging (BCI), for improved detection of subtle lung nodules. In BCI, two digital radiographs of the chest are acquired within a short time interval from slightly different posterior projections. The image data are incorporated into an enhanced Computer-aided Diagnosis (CAD) algorithm in which nodules present in the thoracic cavity are detected by examining the geometrical correlation of the detected signals in the two views. The data are alos viewed stereoscopically for visual diagnosis. The expected high sensitivity/specificity of the method has the potential to change the current state of practice, perhaps leading to a preventive lung cancer screening program for high-risk populations, similar to the mammography screening program currently in place for breast cancer.

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Key information

Conditions

Lung Cancer Lung Diseases Lung Neoplasms Metastatic Cancer in the Lungs Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Duke University Medcal Center

Durham, North Carolina, 27705, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Normal individuals
  • Individuals with CT-confirmed subtle lung nodules.

Exclusion criteria

  • Individuals with acute pulmonary abnormalities or those in poor health conditions will be excluded due to the potential impact on the results as well as difficulty of acquiring the images. Pregnant women will also be excluded to avoid the exposure of the fetus to radiation.

Treatment and study plan

bi-plane chest radiography

Device

Bi-plane radiography of the thorax

Primary outcomes

  1. The technique is effective in diagnosing early lung tumors.

    Time frame: end of the study

Secondary outcomes

  1. The relative performance of BCI with respect to chest radiography and CT for lung cancer detection.

    Time frame: end of the study

Sponsors and collaborators

Lead sponsor

Duke University

Other

Registry information

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
May 7, 2008
Registry last updated
Aug 1, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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